Evidence map›Paper›PMID 34296391›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2022

Suppression of HIV-associated Macrophage Activation by a p75 Neurotrophin Receptor Ligand.

Deirdre A Killebrew, Kimberly S Williams, Youmei Xie, Frank Longo, Rick B Meeker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Inhibition of human macrophage activationFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Deirdre A KillebrewDepartment of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Kimberly S WilliamsDepartment of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Youmei XieDepartment of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Frank LongoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Rick B MeekerDepartment of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA. meekerr@neurology.unc.edu.ORCID 0000-0002-7487-5315
University of North Carolina at Chapel Hill · USStanford University · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Neural network dysfunction in early HIV neuropathogenesisR01NS108808 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2018 to 2022
$1.9M
Neurotrophin mimetic therapeutics for HIV-associated neural dysfunctionR01MH085606 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2009 to 2013
$1.7M
Neurotrophin Protection in HIV and AgingR01NS083164 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2013 to 2016
$1.1M
A degradomics strategy for the analysis of inflammation-associated neuronal vulnerabilityR21AG056924 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2017 to 2018
$428k
Macrophages Role in the Development of HIV LipoatrophyF32HL085025 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KILLEBREW, DEIRDRE A · 2006 to 2008
$145k
Neurotrophin- Chemokine Receptor Interactions Regulate Macrophage ActivationF31MH101019 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAMS, KIMBERLY S. · 2013 to 2014
$65k
NHLBI NIH HHS F32 HL085025NIAID NIH HHS P30 AI050409NIA NIH HHS R21 AG056924NIH HHS F31 MH101019NIH HHS F32 HL085025NIH HHS R01 MH085606NIH HHS R01 NS083164NIH HHS R21 AG056924NIMH NIH HHS F31 MH101019NIMH NIH HHS R01 MH085606NINDS NIH HHS R01 NS083164NINDS NIH HHS R01 NS108808
6 · The paper itself

Abstract

Previous studies indicated that nerve growth factor (NGF) and proNGF differentially regulate the phenotype of macrophages and microglia via actions at tropomyosin receptor kinase A (TrkA) and p75 neurotrophin receptors (p75

Indexed as

HIV InfectionsReceptor, Nerve Growth FactorHumansLigandsMacrophage ActivationLigandsReceptor, Nerve Growth FactorGrowth factorHIVInflammationMicrogliaNeuroprotectionSecretome

Identifiers

PMID34296391
PMCPMC9386897
OpenAlexW3185571546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.