ArticleNeurobiology of language (Cambridge, Mass.)2021
Behavioral and neural correlates of speech motor sequence learning in stuttering and neurotypical speakers: an fMRI investigation.
Article in Neurobiology of language (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Motor Memory Consolidation Deficits in Parkinson's Disease: A Systematic Review with Meta-Analysis.Journal of Parkinson's disease · 2023Pooled it
- Sensory basis of speech motor learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Speech Network in Childhood Stuttering: Differences in Functional Connectivity of the Planning and Motor Loops.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Neural and Behavioral Predictors of Speech Motor Sequence Learning in Primary Progressive Aphasia.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Dataset for Evaluating the Production of Phonotactically Legal and Illegal Pseudowords.Scientific data · 2025Article
- Noninvasive Neurostimulation to the Inferior Frontal Sulcus or Cerebellum Improves Accuracy But Not Timing in a Speech Motor Learning Task.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Evidence for planning and motor subtypes of stuttering based on resting state functional connectivity.Brain and language · 2024Article
- Knowns and unknowns about the neurobiology of stuttering.PLoS biology · 2024Article
- Disentangling Effects of Memory Storage and Inter-articulator Coordination on Generalization in Speech Motor Sequence Learning.Journal of psycholinguistic research · 2023Article
- Neurocomputational modeling of speech motor development.Journal of child language · 2023Review
- Neural Changes in Children With Residual Speech Sound Disorder After Ultrasound Biofeedback Speech Therapy.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Factors Affecting Nonnative Consonant Cluster Learning.Journal of speech, language, and hearing research : JSLHR · 2023Article
- A comparison of structural morphometry in children and adults with persistent developmental stuttering.Brain communications · 2023Article
- Brain activity during the preparation and production of spontaneous speech in children with persistent stuttering.NeuroImage. Clinical · 2023Article
- The Dopamine System and Automatization of Movement Sequences: A Review With Relevance for Speech and Stuttering.Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Stuttering is a neurodevelopmental disorder characterized by impaired production of coordinated articulatory movements needed for fluent speech. It is currently unknown whether these abnormal production characteristics reflect disruptions to brain mechanisms underlying the acquisition and/or execution of speech motor sequences. To dissociate learning and control processes, we used a motor sequence learning paradigm to examine the behavioral and neural correlates of learning to produce novel phoneme sequences in adults who stutter (AWS) and neurotypical controls. Participants intensively practiced producing pseudowords containing non-native consonant clusters (e.g., "gvasf") over two days. The behavioral results indicated that although the two experimental groups showed comparable learning trajectories, AWS performed significantly worse on the task prior to and after speech motor practice. Using functional magnetic resonance imaging (fMRI), the authors compared brain activity during articulation of the practiced words and a set of novel pseudowords (matched in phonetic complexity). FMRI analyses revealed no differences between AWS and controls in cortical or subcortical regions; both groups showed comparable increases in activation in left-lateralized brain areas implicated in phonological working memory and speech motor planning during production of the novel sequences compared to the practiced sequences. Moreover, activation in left-lateralized basal ganglia sites was negatively correlated with in-scanner mean disfluency in AWS. Collectively, these findings demonstrate that AWS exhibit no deficit in constructing new speech motor sequences but do show impaired execution of these sequences before and after they have been acquired and consolidated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.