ArticleCerebral cortex communications2020
Rapid Rule-Based Reward Reversal and the Lateral Orbitofrontal Cortex.
Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Mental Scene and Memory Construction and the Hippocampus.Hippocampus · 2026Article
- Internal connectivity of the mouse mesocortical ring and functional implications.Brain structure & function · 2026Article
- Functional connectome fingerprinting related to BMI and its association with impulsivity.Brain imaging and behavior · 2025Article
- Emotion, Motivation, Reasoning, and How Their Brain Systems Are Related.Brain sciences · 2025Review
- Hippocampal Discoveries: Spatial View Cells, Connectivity, and Computations for Memory and Navigation, in Primates Including Humans.Hippocampus · 2025Review
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia.Brain : a journal of neurology · 2024Review
- Aspiration removal of orbitofrontal cortex disrupts cholinergic fibers of passage to anterior cingulate cortex in rhesus macaques.Brain structure & function · 2024Article
- Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment.Molecular psychiatry · 2024Review
- Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala.Brain structure & function · 2023Review
- Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans.Hippocampus · 2023Review
- Morphometry of the lateral orbitofrontal cortex is associated with eating dispositions in early adolescence: findings from a large population-based study.Social cognitive and affective neuroscience · 2023Article
- The orbitofrontal cortex, food reward, body weight and obesity.Social cognitive and affective neuroscience · 2023Article
- The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation.Human brain mapping · 2023Article
- Attractor cortical neurodynamics, schizophrenia, and depression.Translational psychiatry · 2021Review
- Precision Mental Health Care for Cannabis Use Disorder: Utility of a bioSocial Cognitive Theory to Inform Treatment.Frontiers in psychiatry · 2021Review
- The orbitofrontal cortex: reward, emotion and depression.Brain communications · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans and other primates can reverse their choice of stimuli in one trial when the rewards delivered by the stimuli change or reverse. Rapidly changing our behavior when the rewards change is important for many types of behavior, including emotional and social behavior. It is shown in a one-trial rule-based Go-NoGo deterministic visual discrimination reversal task to obtain points, that the human right lateral orbitofrontal cortex and adjoining inferior frontal gyrus is activated on reversal trials, when an expected reward is not obtained, and the non-reward allows the human to switch choices based on a rule. This reward reversal goes beyond model-free reinforcement learning. This functionality of the right lateral orbitofrontal cortex shown here in very rapid, one-trial, rule-based changes in human behavior when a reward is not received is related to the emotional and social changes that follow orbitofrontal cortex damage, and to depression in which this non-reward system is oversensitive and over-connected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.