Evidence map›Paper›PMID 34296137›Full record

ArticleCerebral cortex communications2020

Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control.

Yufen Chen, Amy A Herrold, Zoran Martinovich, Sumra Bari, Nicole L Vike, Anne J Blood, Alexa E Walter, Jaroslaw Harezlak, Peter H Seidenberg, Manish Bhomia and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Yufen ChenCenter for Translational Imaging, Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Amy A HerroldEdward Hines Jr., VA Hospital, Research Service, Hines, IL 60141, USA.
Zoran MartinovichMental Health Services and Policy Program, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Sumra BariWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Nicole L VikeWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Anne J BloodMood and Motor Control Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Alexa E WalterDepartment of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA.
Jaroslaw HarezlakDepartment of Epidemiology and Biostatistics, Indiana University, Bloomington, IN 47405, USA.
Peter H SeidenbergDepartments of Orthopaedics & Rehabilitation and Family & Community Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
Manish BhomiaDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Barbara Knollmann-RitschelDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Khrystyna StetsivWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
James L ReillyWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Eric A NaumanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Thomas M TalavageSchool of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA.
Linda PapaDepartment of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA.
Semyon SlobounovDepartment of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA.
Hans C BreiterWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Concussion Neuroimaging Consortium
Northwestern University · USPennsylvania State University · USPurdue University West Lafayette · USUniformed Services University of the Health Sciences · USHarvard University · USIndiana University Bloomington · USOrlando Regional Medical Center · USPenn State Milton S. Hershey Medical Center · US

Funding

Biomarkers of Mild and Moderate Traumatic Brain InjuryR01NS057676 · NINDS · ORLANDO REGIONAL HEALTHCARE SYSTEM, INC. · PI PAPA, LINDA · 2008 to 2022
$5.8M
NINDS NIH HHS R01 NS057676
6 · The paper itself

Abstract

Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of "imaging omics." Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel's test

Indexed as

football athleteshead acceleration eventsmicroRNAspostural controlregional cerebral blood flow

Identifiers

PMID34296137
PMCPMC8153038
OpenAlexW3097421336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.