ArticleCerebral cortex communications2020
Temporal Learning Among Prefrontal and Striatal Ensembles.
Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Article
- Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice.bioRxiv : the preprint server for biology · 2024Article
- Stable sequential dynamics in prefrontal cortex represents subjective estimation of time.eLife · 2024Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Neurocomputational Models of Interval Timing: Seeing the Forest for the Trees.Advances in experimental medicine and biology · 2024Review
- Glycolysis-enhancing αNPJ Parkinson's disease · 2023Article
- Context-specific and context-invariant computations of interval timing.Frontiers in neuroscience · 2023Article
- Novelty-induced frontal-STN networks in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The neural bases for timing of durations.Nature reviews. Neuroscience · 2022Review
- Functional architecture of executive control and associated event-related potentials in macaques.Nature communications · 2022Article
- Article
- Mice expressing P301S mutant human tau have deficits in interval timing.Behavioural brain research · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- Experience-related enhancements in striatal temporal encoding.The European journal of neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Behavioral flexibility requires the prefrontal cortex and striatum, but it is unclear if these structures play similar or distinct roles in adapting to novel circumstances. Here, we investigate neuronal ensembles in the medial frontal cortex (MFC) and the dorsomedial striatum (DMS) during one form of behavioral flexibility: learning a new temporal interval. We studied corticostriatal neuronal activity as rodents trained to respond after a 12-s fixed interval (FI12) learned to respond at a shorter 3-s fixed interval (FI3). On FI12 trials, we found that a key form of temporal processing-time-related ramping activity-decreased in the MFC but did not change in the DMS as animals learned to respond at a shorter interval. However, while MFC and DMS ramping was stable with successive days of two-interval performance, temporal decoding by DMS ensembles improved on FI3 trials. Finally, when comparing FI12 versus FI3 trials, we found that more DMS neurons than MFC neurons exhibited differential interval-related activity early in two-interval performance. These data suggest that the MFC and DMS play distinct roles during temporal learning and provide insight into corticostriatal circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.