Evidence map›Paper›PMID 34296117›Full record

ArticleCerebral cortex communications2020

In-Depth Characterization of Layer 5 Output Neurons of the Primary Somatosensory Cortex Innervating the Mouse Dorsal Spinal Cord.

N Frezel, E Platonova, F F Voigt, J M Mateos, R Kastli, U Ziegler, T Karayannis, F Helmchen, H Wildner, H U Zeilhofer

Open access · hybridAbstract read
In one paragraph

Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Neuropathic Pain-Like Responses in a Chronic CNS Injury Model Are Mediated by Corticospinal-Targeted Spinal Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Review
  8. A sensory-motor theory of the neocortex.Nature neuroscience · 2024
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

N FrezelInstitute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zürich, Switzerland.ORCID 0000-0002-5812-6664
E PlatonovaCenter for Microscopy and Image Analysis, University of Zurich, CH-8057 Zürich CH-8057, Switzerland.
F F VoigtBrain Research Institute, University of Zurich, CHJ-8057 Zurich CH-8057 , Switzerland.
J M MateosCenter for Microscopy and Image Analysis, University of Zurich, CH-8057 Zürich CH-8057, Switzerland.
R KastliBrain Research Institute, University of Zurich, CHJ-8057 Zurich CH-8057 , Switzerland.
U ZieglerCenter for Microscopy and Image Analysis, University of Zurich, CH-8057 Zürich CH-8057, Switzerland.
T KarayannisBrain Research Institute, University of Zurich, CHJ-8057 Zurich CH-8057 , Switzerland.
F HelmchenBrain Research Institute, University of Zurich, CHJ-8057 Zurich CH-8057 , Switzerland.
H WildnerInstitute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zürich, Switzerland.ORCID 0000-0001-5075-6269
H U ZeilhoferInstitute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zürich, Switzerland.ORCID 0000-0001-6954-4629
University of Zurich · CH

Funding

European Research Council 670757
6 · The paper itself

Abstract

Neuronal circuits of the spinal dorsal horn integrate sensory information from the periphery with inhibitory and facilitating input from higher central nervous system areas. Most previous work focused on projections descending from the hindbrain. Less is known about inputs descending from the cerebral cortex. Here, we identified cholecystokinin (CCK) positive layer 5 pyramidal neurons of the primary somatosensory cortex (CCK

Indexed as

AAV-based viral tracingCCKcorticospinal tractdorsal spinal cordsomatosensory cortex

Identifiers

PMID34296117
PMCPMC8152836
OpenAlexW3080904564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.