Evidence map›Paper›PMID 34296084›Full record

ArticleCerebral cortex communications2020

Examining the Progressive Behavior and Neuropathological Outcomes Associated with Chronic Repetitive Mild Traumatic Brain Injury in Rats.

Eric Eyolfson, Glenn R Yamakawa, Yannick Griep, Reid Collins, Thomas Carr, Melinda Wang, Alexander W Lohman, Richelle Mychasiuk

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Eric EyolfsonDepartment of Psychology, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
Glenn R YamakawaDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
Yannick GriepDepartment of Psychology, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
Reid CollinsDepartment of Psychology, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
Thomas CarrDepartment of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
Melinda WangDepartment of Psychology, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
Alexander W LohmanDepartment of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
Richelle MychasiukDepartment of Psychology, Alberta Children's Hospital Research Institute, The University of Calgary, Calgary, AB, T2N 1N4, Canada.
University of Calgary · CAMonash University · AUAlberta Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the physical and behavioral symptomologies associated with a single mild traumatic brain injury (mTBI) are typically transient, repetitive mTBIs (RmTBI) have been associated with persisting neurological deficits. Therefore, this study examined the progressive changes in behavior and the neuropathological outcomes associated with chronic RmTBI through adolescence and adulthood in male and female Sprague Dawley rats. Rats experienced 2 mTBIs/week for 15 weeks and were periodically tested for changes in motor behavior, cognitive function, emotional disturbances, and aggression. Brain tissue was examined for neuropathological changes in ventricle size and presentation of Iba1 and GFAP. We did not see progressively worse behavioral impairments with the accumulation of injuries or time, but did find evidence for neurological and functional change (motor disturbance, reduced exploration, reduced aggression, alteration in depressive-like behavior, deficits in short-term working memory). Neuropathological assessment of RmTBI animals identified an increase in ventricle size, prolonged changes in GFAP, and sex differences in Iba1, in the corpus callosum, thalamus, and medial prefrontal cortex. Telomere length reduced exponentially as the injury load increased. Overall, chronic RmTBI did not result in accumulating behavioral impairment, and there is a need to further investigate progressive behavioral changes associated with repeated injuries in adolescence and young adulthood.

Indexed as

adolescenceconcussionGFAPIBA1sex differencestelomere length

Identifiers

PMID34296084
PMCPMC8152839
OpenAlexW3007424747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.