ArticleClinical and experimental hepatology2021
Variant etiologies of neonatal cholestasis and their outcome: a Middle East single-center experience.
Article in Clinical and experimental hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Association of Autophagy-Related Gene 5 (ATG5) With Neonatal Cholestasis in Egyptian Pediatric Patients.Iranian journal of pathology · 2025Article
- Does amyloid β precursor protein gene expression have a role in diagnosis of biliary atresia?Clinical and experimental hepatology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
aim of the studyNeonatal cholestasis (NC) constitutes a large proportion of pediatric liver disorders. Nevertheless, awareness of the variant etiologies and how to manage them appropriately are lacking. So, out of a few specialized centers, many cases pass without appropriate management. This study aimed to present our tertiary level center's experience in NC that could increase the pediatrician's awareness of handling this problematic and common medical morbidity efficiently. MATERIAL AND
methodsIt is a retrospective study in which we analyzed the NC cases admitted to the inpatient department within three years. For all recruited patients, the available data were retrieved and recorded.
resultsA total of 412 patients were reviewed with 20 different etiologies diagnosed. The most common cause was biliary atresia (
conclusionsNC constitutes more than one-third of the inpatient admissions of all pediatric liver disorders and has a high rate of mortality. Awareness of the variety of etiologies and a rapid stepwise approach to diagnosis could have an impact on the outcome of this devastating disease.
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