ArticleSurgery journal (New York, N.Y.)2021
Appendicitis Inflammatory Response Score in Comparison to Alvarado Score in Acute Appendicitis.
Article in Surgery journal (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children.BJS open · 2025Guideline
- Diagnostic value of the appendicitis inflammatory response (AIR) score. A systematic review and meta-analysis.World journal of emergency surgery : WJES · 2025Pooled it
- Comparison of the Alvarado Score with Alternative Diagnostic Tools in Pediatric Acute Appendicitis: A Literature Review.Pediatric reports · 2026Review
- A novel CT-based scoring system for appendicoliths and its prognostic value in acute appendicitis: a retrospective cohort study.Emergency radiology · 2026Article
- The CHANSE score: a novel clinical tool incorporating the heel drop test for the diagnosis of pediatric appendicitis.Frontiers in pediatrics · 2025Article
- Can the Combination of White Blood Cell Count and C-Reactive Protein Rule Out Pediatric Appendicitis, a Retrospective Analysis?HCA healthcare journal of medicine · 2025Article
- Assessment of Alvarado criteria, ultrasound, CRP, and their combination in patients with suspected acute appendicitis: a single centre study.BMC gastroenterology · 2024Article
- Observational
- Validation and comparison of two new scoring systems for the prediction of complicated versus uncomplicated appendicitis.Irish journal of medical science · 2024Article
- Review
- Prediction of Perforated and Nonperforated Acute Appendicitis Using Machine Learning-Based Explainable Artificial Intelligence.Diagnostics (Basel, Switzerland) · 2023Article
- The Diagnostic Differentiation Challenge in Acute Appendicitis: How to Distinguish between Uncomplicated and Complicated Appendicitis in Adults.Diagnostics (Basel, Switzerland) · 2022Review
- Hospitalization Trends for Acute Appendicitis in Spain, 1998 to 2017.International journal of environmental research and public health · 2021Observational
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appendicitis is a common differential diagnosis of right lower quadrant pain. Clinical evaluation alone results in high negative appendicectomy rates. Alvarado scoring is the most commonly used clinical prediction rule. The study aimed to compare the recently developed appendicitis inflammatory response (AIR) score with the Alvarado score. This cross-sectional observational study included patients who underwent appendicectomy for clinical suspicion of appendicitis. The clinical and laboratory parameters required for obtaining Alvarado score and AIRS were gathered. Area under ROC curve was calculated for both Alvarado score and AIRS. The study included 130 patients (77 males and 53 females). The negative appendicectomy rate was 10.7%. The perforation rate was 10.3%. The area under ROC for Alvarado score was 0.821 and for AIR score was 0.901. The Alvarado score had a sensitivity of 72% and a specificity of 79% at score ≥6. The appendicitis inflammatory response score had a sensitivity of 98% for scores ≥5 and a specificity of 97% for score ≥6. The C-reactive protein (CRP) value was the best performing individual parameter with an area under ROC of 0.789, followed by WBC count with an area under ROC of 0.762. Appendicitis inflammatory response score is a recently developed score that outperforms the Alvarado score. AIR score has a higher specificity. The sound construction, gradation of parameters, the inclusion of CRP, and avoidance of subjective parameters make the AIR score an attractive clinical prediction rule which can decrease the rate of negative appendicectomy.
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