Evidence map›Paper›PMID 34295905›Full record

ArticleFrontiers in medicine2021

METTL3 Promotes Activation and Inflammation of FLSs Through the NF-κB Signaling Pathway in Rheumatoid Arthritis.

Wen Shi, Yan Zheng, Shuai Luo, Xiaofeng Li, Yilong Zhang, Xiaoming Meng, Cheng Huang, Jun Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. mMolecular medicine reports · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. METTL3-mCellular & molecular biology letters · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Transcriptional Regulation ofInternational journal of molecular sciences · 2025
    Article
  15. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  16. Article
  17. METTL3: a multifunctional regulator in diseases.Molecular and cellular biochemistry · 2025
    Review
  18. IGF2BP3-mediated mBone research · 2025
    Article
  19. The Role of MClinical reviews in allergy & immunology · 2025
    Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wen ShiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Yan ZhengInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Shuai LuoInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Xiaofeng LiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Yilong ZhangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Xiaoming MengInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Cheng HuangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Jun LiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Anhui Medical University · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and development of RA. Methyltransferase-like 3 (METTL3), which is a crucial component of the

Indexed as

FLSsinflammatory responseinvasionMETTL3migrationproliferationrheumatoid arthritis

Identifiers

PMID34295905
PMCPMC8290917
OpenAlexW3177725972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.