Evidence map›Paper›PMID 34295821›Full record

ArticleFrontiers in oncology2021

Long Non-Coding RNA LINC00152 Regulates Self-Renewal of Leukemia Stem Cells and Induces Chemo-Resistance in Acute Myeloid Leukemia.

Chunhong Cui, Yan Wang, Wenjie Gong, Haiju He, Hao Zhang, Wei Shi, Hui Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Chunhong CuiShanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Yan WangHuashan Hospital, Fudan University, Shanghai, China.
Wenjie GongDepartment of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China.
Haiju HeDepartment of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China.
Hao ZhangHuashan Hospital, Fudan University, Shanghai, China.
Wei ShiHuashan Hospital, Fudan University, Shanghai, China.
Hui WangShanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Fudan University · CNShanghai University of Medicine and Health Sciences · CNFirst Affiliated Hospital of Soochow University · CNHuashan Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relapse of acute myeloid leukemia (AML) has a very poor prognosis and remains a common cause of treatment failure in patients with this disease. AML relapse is partially driven by the chemoresistant nature of leukemia stem cells (LSCs), which remains poorly understood, and our study aimed at elucidating the underlying mechanism. Accumulating evidences show that long noncoding RNAs (lncRNAs) play a crucial role in AML development. Herein, the lncRNA, LINC00152, was identified to be highly expressed in CD34

Indexed as

chemo-resistanceleukemialeukemia stem cellsLINC00152poly (ADP-ribose) polymerase 1

Identifiers

PMID34295821
PMCPMC8290167
OpenAlexW3179104254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.