ArticleTranslational lung cancer research2021
Should resection extent be decided by total lesion size or solid component size in ground glass opacity-containing lung adenocarcinomas?
Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Application of three-dimensional technology in video-assisted thoracoscopic surgery sublobectomy.Frontiers in oncology · 2024Pooled it
- Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis.World journal of surgical oncology · 2023Pooled it
- Marginal benefit of segmentectomy over lobectomy in minimally invasive surgery for stage IA lung cancer.Translational lung cancer research · 2026Article
- GAN-generated target reconstruction CT radiomics for prediction of the novel IASLC grading of pulmonary adenocarcinoma.Journal of thoracic disease · 2026Article
- Sublobar resection is the preferred surgical strategy for clinical stage IA lung cancers presenting as subsolid nodule.JTCVS open · 2026Article
- Is surgical lymph node assessment justified for ground glass opacity-dominant lung adenocarcinoma?Frontiers in oncology · 2026Article
- Risk factors and clinical risk stratification of distant metastasis in early-stage lung cancer in never smokers.World journal of surgical oncology · 2025Article
- Article
- The Solid Volume Ratio is Better Than the Consolidation Tumor Ratio in Predicting the Malignant Pathological Features of cT1 Lung Adenocarcinoma.The Thoracic and cardiovascular surgeon · 2025Article
- Exploring the optimal threshold of 3D consolidation tumor ratio value segmentation based on artificial intelligence for predicting the invasive degree of T1 lung adenocarcinoma.Quantitative imaging in medicine and surgery · 2024Article
- Tumor size, but not consolidation-to-tumor ratio, is an independent prognostic factor for part-solid clinical T1 non-small cell lung cancer.Thoracic cancer · 2023Review
- A rare case report: co-occurrence of two types of lung cancer with hamartoma and pulmonary tuberculosis.Frontiers in oncology · 2023Article
- Ground glass opacity resection extent assessment trialFrontiers in oncology · 2023Article
- Clinical features and surgical outcomes of young patients with lung adenocarcinoma manifesting as ground glass opacity.Frontiers in oncology · 2022Article
- Sequential pulmonary resections by uniportal video-assisted thoracic surgery for bilateral multiple pulmonary nodules.Frontiers in oncology · 2022Article
- What Do We Talk About Now When We Talk About Segmentectomy for GGO?Frontiers in surgery · 2022Review
- A predictive nomogram for lymph node metastasis in part-solid invasive lung adenocarcinoma: A complement to the IASLC novel grading system.Frontiers in oncology · 2022Article
- A combination of radiomic features, clinic characteristics, and serum tumor biomarkers to predict the possibility of the micropapillary/solid component of lung adenocarcinoma.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndication for sublobar resections in early-stage lung adenocarcinomas has been controversial. The purpose of this study was to find appropriate selection criteria for sublobar resections in ground glass opacity (GGO)-containing early-stage lung adenocarcinomas.
methodsWe retrospectively studied 985 consecutive patients with clinical stage IA, peripheral GGO-containing lung adenocarcinomas ≤3 cm in size. According to their radiological appearance, they were divided into a pure GGO group and a part-solid nodule (PSN) group. The PSN group was further divided into a GGO-predominant subgroup and a solid-predominant subgroup. Propensity-score matching (PSM) was conducted first in PSNs with similar total lesion size and then in those with similar solid component size to eliminate potential confounders. Histological characteristics and prognosis were compared between matched patients to investigate the prognostic value of total lesion size and solid component size. Then solid component size was chosen as the selection criterion to compare the prognosis of patients receiving lobectomy or sublobar resections.
resultsComparing to PSNs, pure GGO lesions had significantly more favorable histological characteristics and prognosis, with 100% 5-year overall survival (OS), even though 33.3% of patients with pure GGO lesions >20 mm in total lesion size received sublobar resections. For 157 pairs of PSNs with similar total lesion size but different solid component size after the first PSM, the solid-predominant subgroup had significantly worse histological characteristics and prognosis than the GGO-predominant subgroup. After the second PSM, histological characteristics and prognosis were comparable between 73 pairs of PSNs with similar solid component size but different total lesion size. Multivariable analysis showed that solid component size, rather than total lesion size or consolidation-to-tumor ratio (CTR), was an independent prognostic factor. For PSNs containing solid component size ≤2 cm, relapse-free survival (RFS) was similar after sublobar resections or lobectomy (95.0%
conclusionsSolid component size better predicts histological characteristics and prognosis than total lesion size in early-stage GGO-containing lung adenocarcinomas. Instead of total lesion size, solid component size ≤2 cm may be a more appropriate selection criterion for sublobar resections in such patients.
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