Evidence map›Paper›PMID 34295569›Full record

ArticleACS catalysis2020

A Growth-Based, High-Throughput Selection Platform Enables Remodeling of 4-Hydroxybenzoate Hydroxylase Active Site.

Sarah Maxel, Derek Aspacio, Edward King, Linyue Zhang, Ana Paula Acosta, Han Li

Open access · greenAbstract read
In one paragraph

Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. EngineeringACS catalysis · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah MaxelDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, California 92697, United States.
Derek AspacioDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, California 92697, United States.
Edward KingDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, United States.
Linyue ZhangDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, California 92697, United States.
Ana Paula AcostaDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, California 92697, United States.
Han LiDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0002-6113-6433
University of California, Irvine · US

Funding

Engineering an unnatural redox cofactor (uRedox) system for efficient biosynthesis of medicinesDP2GM137427 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, HAN · 2019 to 2022
$2.4M
NIGMS NIH HHS DP2 GM137427
6 · The paper itself

Abstract

We report an aerobic, growth-based selection platform founded on NADP(H) redox balance restoration in

Indexed as

3,4-dihydroxybenzoic acid4-hydroxybenzoate hydroxylasedirected evolutionNADPH-dependent monooxygenaseredox balance

Identifiers

PMID34295569
PMCPMC8294663
OpenAlexW3033444453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.