Evidence map›Paper›PMID 34295537›Full record

ArticleFuture science OA2021

Combined bone scintigraphy and fluorocholine PET/computed tomography predicts response to radium-223 therapy in patients with prostate cancer.

Michele Klain, Valeria Gaudieri, Mario Petretta, Emilia Zampella, Giovanni Storto, Carmela Nappi, Carlo Buonerba, Felice Crocetto, Rosj Gallicchio, Fabio Volpe and 3 more

Open access · goldAbstract read
In one paragraph

Article in Future science OA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Metastatic castration-resistant prostate cancer therapy: the quest for the perfect molecule.European journal of nuclear medicine and molecular imaging · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Michele KlainDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Valeria GaudieriDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Mario PetrettaIRCCS SDN, Diagnostic Imaging, Naples, Italy.
Emilia ZampellaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Giovanni StortoNuclear Medicine Unit, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Carmela NappiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Carlo BuonerbaDepartment of Oncology & Hematology, Regional Reference Center for Rare Tumors, AOU Federico II of Naples, Naples, Italy.
Felice CrocettoDepartment of Neurosciences, Human Reproduction & Odontostomatology, University of Naples Federico II, Naples, Italy.
Rosj GallicchioNuclear Medicine Unit, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Fabio VolpeDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Leonardo PaceDepartment of Medicine, Surgery & Dentistry, University of Salerno, Salerno, Italy.
Martin SchlumbergerDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Alberto CuocoloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0003-3431-7658
University of Naples Federico II · ITCentro di Riferimento Oncologico della Basilicata · ITSDN Istituto di Ricerca Diagnostica e Nucleare · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the value of bone scintigraphy and MATERIALS &

methodsRetrospective analysis of 48 patients that underwent

resultsAfter therapy, pain relief was observed in 27 patients. Patients without pain relief had more bone lesions at PET/CT than at bone scintigraphy (pretherapy imaging mismatch). In 39 patients who completed treatment protocol, post-therapy alkaline phosphatase and pretherapy imaging mismatch were independent predictors of poor overall survival.

conclusionPatients with more lesions at

Indexed as

18F-fluorocholine PET/CT outcome223radiumbone scintigraphyprostate cancer

Identifiers

PMID34295537
PMCPMC8288237
OpenAlexW3161784361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.