Evidence map›Paper›PMID 34295441›Full record

ReviewCellular and molecular bioengineering2021

Immune System Effects on Breast Cancer.

Jensen N Amens, Gökhan Bahçecioglu, Pinar Zorlutuna

Abstract readReview
In one paragraph

Review in Cellular and molecular bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  15. A novel preclinical model of the normal human breast.Journal of mammary gland biology and neoplasia · 2024
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jensen N AmensDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556 USA.
Gökhan BahçeciogluDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556 USA.
Pinar ZorlutunaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556 USA.ORCID 0000-0002-3122-7553

Funding

An Engineered Tissue Model of Aged Mammary MicroenvironmentR01EB027660 · NIBIB · UNIVERSITY OF NOTRE DAME · PI ZORLUTUNA, PINAR · 2019 to 2022
$1.6M
NIBIB NIH HHS R01 EB027660
6 · The paper itself

Abstract

Breast cancer is one of the most common cancers in women, with the ability to metastasize to secondary organs, which is the main cause of cancer-related deaths. Understanding how breast tumors progress is essential for developing better treatment strategies against breast cancer. Until recently, it has been considered that breast cancer elicits a small immune response. However, it is now clear that breast tumor progression is either prevented by the action of antitumor immunity or exacerbated by proinflammatory cytokines released mainly by the immune cells. In this comprehensive review we first explain antitumor immunity, then continue with how the tumor suppresses and evades the immune response, and next, outline the role of inflammation in breast tumor initiation and progression. We finally review the current immunotherapeutic and immunoengineering strategies against breast cancer as a promising emerging approach for the discovery and design of immune system-based strategies for breast cancer treatment.

Indexed as

Antitumor immunityBreast cancer progressionImmune cellsimmune engineeringImmune evasionImmune suppressionImmunotherapyProinflammatory cytokines

Identifiers

PMID34295441
PMCPMC8280260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.