Evidence map›Paper›PMID 34295276›Full record

SynthesisFrontiers in psychiatry2021

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis.

Frédéric Dutheil, Sarah de Saint Vincent, Bruno Pereira, Jeannot Schmidt, Farès Moustafa, Morteza Charkhabi, Jean-Baptiste Bouillon-Minois, Maëlys Clinchamps

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06860581 (The Impact of Dietary Supplementation With Lactobacillus Helveticus and Bifidobacterium Longum on the Functioning of the Brain-gut Axis, in the Context of Mental Health, Eating Patterns and Nutritional Status of Young Adults), which is not on this map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
7.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06860581 nacompletednot on this mapstarted 2023, after this paper: background citation

The Impact of Dietary Supplementation With Lactobacillus Helveticus and Bifidobacterium Longum on the Functioning of the Brain-gut Axis, in the Context of Mental Health, Eating Patterns and Nutritional Status of Young Adults

TypeinterventionalSponsorPoznan University of Life SciencesRan2023 to 2024Enrolled120ConditionsHealthy Volunteers, Young Adult, WomenArmsIntervention (Sanprobi®Stress), Placebo
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Biological Markers of Burnout Severity: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. The effect of stress on testosterone and sexual function.International journal of impotence research · 2026
    Review
  8. Article
  9. Article
  10. Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  11. Article
  12. Article
  13. Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Frédéric DutheilUniversité Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, Occupational and Environmental Medicine, Wittyfit, Clermont-Ferrand, France.
Sarah de Saint VincentUniversité Clermont Auvergne, Occupational and Environmental Medicine, Clermont-Ferrand, France.
Bruno PereiraCHU Clermont-Ferrand, CHU Clermont-Ferrand, Clinical Research and Innovation Direction, Clermont-Ferrand, France.
Jeannot SchmidtUniversité Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, Emergency Department, Clermont-Ferrand, France.
Farès MoustafaUniversité Clermont Auvergne, CHU Clermont-Ferrand, Emergency Department, Clermont-Ferrand, France.
Morteza CharkhabiUniversité Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, Clermont-Ferrand, France.
Jean-Baptiste Bouillon-MinoisUniversité Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, Emergency Department, Clermont-Ferrand, France.
Maëlys ClinchampsCHU Clermont-Ferrand, CHU Clermont-Ferrand, Occupational and Environmental Medicine, Clermont-Ferrand, France.
Centre National de la Recherche Scientifique · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRUniversity of Clermont Auvergne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkersDHEAHPA axispsychosocial stressstress

Identifiers

PMID34295276
PMCPMC8290065
OpenAlexW3180625107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.