Evidence map›Paper›PMID 34295240›Full record

ArticleFrontiers in aging neuroscience2021

Tobacco Smoking Increases Methylation of Polypyrimidine Tract Binding Protein 1 Promoter in Intracranial Aneurysms.

Zhepei Wang, Shengjun Zhou, Jikuang Zhao, Sheng Nie, Jie Sun, Xiang Gao, Cameron Lenahan, Zhiqin Lin, Yi Huang, Gao Chen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Epigenetic mechanisms in aneurysm formation, growth, and rupture: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhepei WangDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Shengjun ZhouDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Jikuang ZhaoDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Sheng NieDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Jie SunDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Xiang GaoDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Cameron LenahanBurrell College of Osteopathic Medicine, Las Cruces, NM, United States.
Zhiqin LinDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Yi HuangDepartment of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.
Gao ChenDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University · CNNingbo University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation at the gene promoter region is reportedly involved in the development of intracranial aneurysm (IA). This study aims to investigate the methylation levels of polypyrimidine tract-binding protein 1 (

Indexed as

CpG islandDNA Methylationintracranal aneurysmpolypyrimidine tract binding protein 1tobacco smoking

Identifiers

PMID34295240
PMCPMC8292010
OpenAlexW3178603528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.