Evidence map›Paper›PMID 34295224›Full record

ArticleFrontiers in neural circuits2021

Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner.

Nicholas Chaaya, Joshua Wang, Angela Jacques, Kate Beecher, Michael Chaaya, Andrew Raymond Battle, Luke R Johnson, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlett

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neural circuits, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nicholas ChaayaSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Joshua WangSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Angela JacquesSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Kate BeecherSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Michael ChaayaSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Andrew Raymond BattleTranslational Research Institute, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Luke R JohnsonTranslational Research Institute, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Fatemeh ChehrehasaTranslational Research Institute, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Arnauld BelmerSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Selena E BartlettSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Translational Research Institute · AUQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a debilitating and chronic fear-based disorder. Pavlovian fear conditioning protocols have long been utilised to manipulate and study these fear-based disorders. Contextual fear conditioning (CFC) is a particular Pavlovian conditioning procedure that pairs fear with a particular context. Studies on the neural mechanisms underlying the development of contextual fear memories have identified the medial prefrontal cortex (mPFC), or more specifically, the pre-limbic cortex (PL) of the mPFC as essential for the expression of contextual fear. Despite this, little research has explored the role of the PL in contextual fear memory maintenance or examined the role of neuronal mitogen-activated protein kinase (pMAPK; ERK 1/2), brain-derived neurotrophic factor (BDNF), and IBA-1 in microglia in the PL as a function of Pavlovian fear conditioning. The current study was designed to evaluate how the maintenance of two different long-term contextual fear memories leads to changes in the number of immune-positive cells for two well-known markers of neural activity (phosphorylation of MAPK and BDNF) and microglia (IBA-1). Therefore, the current experiment is designed to assess the number of immune-positive pMAPK and BDNF cells, microglial number, and morphology in the PL following CFC. Specifically, 2 weeks following conditioning, pMAPK, BDNF, and microglia number and morphology were evaluated using well-validated antibodies and immunohistochemistry (

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCalcium-Binding ProteinsConditioning, ClassicalElectric StimulationFearGene ExpressionMaleMemoryMicrofilament ProteinsMitogen-Activated Protein Kinase KinasesPrefrontal CortexRatsRats, Sprague-DawleyStress Disorders, Post-TraumaticAif1 protein, ratBdnf protein, ratBrain-Derived Neurotrophic FactorCalcium-Binding ProteinsMicrofilament ProteinsMitogen-Activated Protein Kinase Kinasesbrain derived neurotrophic factor (BDNF)fearlearning and memoryplasticityprelimbic cortex

Identifiers

PMID34295224
PMCPMC8291085
OpenAlexW3179000440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.