Evidence map›Paper›PMID 34295156›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2021

Inhaled Corticosteroid Therapy in Bronchiectasis is Associated with All-Cause Mortality: A Prospective Cohort Study.

Kjell E J Håkansson, Katrine Fjaellegaard, Andrea Browatzki, Melda Dönmez Sin, Charlotte Suppli Ulrik

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Inhaled Corticosteroid Use and Risk ofJournal of clinical medicine · 2025
    Article
  3. Article
  4. Article
  5. Inflammatory Phenotypes of Bronchiectasis.Journal of personalized medicine · 2025
    Review
  6. Article
  7. Article
  8. Exacerbations of bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  9. Article
  10. Article
  11. Exacerbation Prevention and Management of Bronchiectasis.Tuberculosis and respiratory diseases · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. The hidden epidemic of post-tuberculosis bronchiectasis.African journal of thoracic and critical care medicine · 2023
    Article
  16. Review
  17. Inhaled corticosteroid dose is associated withBMJ open respiratory research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kjell E J HåkanssonDepartment of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark.ORCID 0000-0001-5804-0740
Katrine FjaellegaardDepartment of Respiratory Medicine, Zealand University Hospital Næstved, Næstved, Denmark.
Andrea BrowatzkiDepartment of Respiratory Medicine, North Zealand Hospital, Hillerød, Denmark.
Melda Dönmez SinDepartment of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark.ORCID 0000-0001-8689-3695
Hvidovre Hospital · DKUniversity of Copenhagen · DKUniversity of Southern Denmark · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Prescribing inhaled corticosteroids (ICS) for bronchiectasis (BE) in the absence of obstructive lung disease is controversial. Studies investigating ICS therapy and impact on morbidity and mortality in BE are sparse. Methods: This study comprises all patients with BE managed at respiratory outpatient clinics at two university hospitals in the Capital Region of Denmark 2014-2015. Baseline data were obtained from patient medical records, and patients were followed until April 2020. Results: Out of 264 patients, 122 (46%) were prescribed ICS with no demographic differences between users/non-users of ICS. Among patients prescribed ICS, 21% did not have a concomitant diagnosis of asthma or COPD. Patients prescribed ICS had lower lung function (median FEV Conclusion: In this cohort, close to one out of five patients with BE were prescribed ICS despite having no concomitant diagnosis of asthma or COPD. Overall, ICS treatment was associated with higher morbidity and mortality, though causation is difficult to establish.

Indexed as

BronchiectasisPulmonary Disease, Chronic ObstructiveAdministration, InhalationAdrenal Cortex HormonesDrug Therapy, CombinationHumansProspective StudiesAdrenal Cortex Hormonesall-cause mortalitydescriptive studyfollow-up cohortICSnon-cystic fibrosis bronchiectasis

Identifiers

PMID34295156
PMCPMC8291380
OpenAlexW3185204850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.