Evidence map›Paper›PMID 34294937›Full record

ReviewPathologica2021

Pathology of non-alcoholic fatty liver disease.

Ivana Cataldo, Samantha Sarcognato, Diana Sacchi, Matilde Cacciatore, Francesca Baciorri, Alessandra Mangia, Nora Cazzagon, Maria Guido

Open access · diamondAbstract readReview
In one paragraph

Review in Pathologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. NSG Mice Lacking Apoe: An Immunodeficient Mouse Model of Atherosclerosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ivana CataldoDepartment of Pathology, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Samantha SarcognatoDepartment of Pathology, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Diana SacchiDepartment of Pathology, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Matilde CacciatoreDepartment of Pathology, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Francesca BaciorriDepartment of Pathology, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Alessandra MangiaLiver Unit, Department of Medical Sciences, Fondazione IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
Nora CazzagonDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Maria GuidoDepartment of Pathology, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Azienda ULSS 9 TREVISO · ITUniversity of Padua · ITCasa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of different conditions which are characterized by hepatic steatosis in the absence of secondary causes. It is currently the most common chronic liver disease worldwide, and its estimated prevalence is about 1.5-6.5%. The only histological finding of steatosis ("simple" steatosis) represents the uncomplicated form of NAFLD, while non-alcoholic steatohepatitis (NASH) is its inflammatory subtype associated with disease progression to cirrhosis and hepatocellular carcinoma (HCC), and represents the major indication for liver transplantation. NASH is still a diagnostic and therapeutic challenge for clinicians and liver biopsy is currently the only accepted method to reliably distinguish NASH from "simple" steatosis. From the histological perspectives, NAFLD and NASH continue to be an area of active interest for pathologists, with a specific focus on better methods of evaluation, morphologic clues to pathogenesis, and predictors of fibrosis progression. This review focuses on histopathology of NAFLD in adults, with the aim to provide a practical diagnostic approach useful in the clinical routine.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNon-alcoholic Fatty Liver DiseaseAdultBiopsyDisease ProgressionHumansLiver Cirrhosisfatty livermetabolic syndromenon-alcoholicsteatohepatitis

Identifiers

PMID34294937
PMCPMC8299321
OpenAlexW3183050172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.