Evidence map›Paper›PMID 34294936›Full record

ReviewPathologica2021

Pathology of autoimmune hepatitis.

Claudia Covelli, Diana Sacchi, Samantha Sarcognato, Nora Cazzagon, Federica Grillo, Francesca Baciorri, Daniela Fanni, Matilde Cacciatore, Valeria Maffeis, Maria Guido

Open access · diamondAbstract readReview
In one paragraph

Review in Pathologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Article
  3. Food science & nutrition · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Observational
  10. Autoimmune Hepatitis Associated with Other Autoimmune Diseases: A Critical Review.Journal of clinical and translational hepatology · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Claudia CovelliPathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Diana SacchiPathology Department Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Samantha SarcognatoPathology Department Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Nora CazzagonDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Federica GrilloUnit of Anatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova and Ospedale Policlinico San Martino IRCCS, Genoa, Italy.
Francesca BaciorriPathology Department Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Daniela FanniPathology Unit, Department of Medical Sciences, University of Cagliari, Cagliari, Italy.
Matilde CacciatorePathology Department Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Valeria MaffeisPathology Department Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Maria GuidoPathology Department Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Azienda ULSS 9 TREVISO · ITUniversity of Padua · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Policlinico San Martino · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune hepatitis (AIH) is a relatively rare non-resolving chronic liver disease, which mainly affects women. It is characterized by hypergammaglobulinemia, circulating autoantibodies, interface hepatitis on liver histology and a favourable response to immunosuppression. The putative mechanism for the development of autoimmune hepatitis is thought to be the interaction between genetic predisposition, environmental triggers and failure of the native immune system. AIH still remains a major diagnostic and therapeutic challenge, mainly because it is a very heterogeneous disease. Prompt and timely diagnosis is crucial since, if left untreated, AIH has a high mortality rate. Histological demonstration of hepatitis is required for the diagnosis of AIH and, therefore, liver biopsy is mandatory in the initial diagnostic work-up, before treatment. In this review, we summarize the histological features of AIH with the main aim of highlighting the most important clinical-pathological hallmarks useful in the routine diagnostic practice.

Indexed as

Hepatitis, AutoimmuneAutoantibodiesFemaleHumansImmunosuppression TherapyAutoantibodiesautoimmune hepatitishistologyinterface hepatitisliver biopsy

Identifiers

PMID34294936
PMCPMC8299324
OpenAlexW3180115438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.