Evidence map›Paper›PMID 34294934›Full record

ReviewPathologica2021

Cholangiocarcinoma.

Samantha Sarcognato, Diana Sacchi, Matteo Fassan, Luca Fabris, Massimiliano Cadamuro, Giacomo Zanus, Ivana Cataldo, Paola Capelli, Francesca Baciorri, Matilde Cacciatore and 1 more

Open access · diamondAbstract readReview
In one paragraph

Review in Pathologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 3 pooled it
25.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 3 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Integrin αvβ3 is a Potential Therapeutic Target in Cholangiocarcinoma.International journal of medical sciences · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Harmonization trial ofPathologica · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Samantha SarcognatoDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Diana SacchiDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Matteo FassanDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Luca FabrisDepartment of Molecular Medicine - DMM, University of Padova, Padova, Italy.
Massimiliano CadamuroDepartment of Molecular Medicine - DMM, University of Padova, Padova, Italy.
Giacomo Zanus4th Surgery Unit, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Ivana CataldoDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Paola CapelliDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
Francesca BaciorriDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Matilde CacciatoreDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Maria GuidoDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Azienda ULSS 9 TREVISO · ITUniversity of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer represents the third leading cause of cancer-related death worldwide. Cholangiocarcinoma (CCA) is the second most common type of liver cancer after hepatocellular carcinoma, accounting for 10-15% of all primary liver malignancies. Both the incidence and mortality of CCA have been steadily increasing during the last decade. Moreover, most CCAs are diagnosed at an advanced stage, when therapeutic options are very limited. CCA may arise from any tract of the biliary system and it is classified into intrahepatic, perihilar, and distal CCA, according to the anatomical site of origin. This topographical classification also reflects distinct genetic and histological features, risk factors, and clinical outcomes. This review focuses on histopathology of CCA, its differential diagnoses, and its diagnostic pitfalls.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaBile Ducts, IntrahepaticHumansbiliarycholangiocarcinomamalignantneoplasiasubtypes

Identifiers

PMID34294934
PMCPMC8299326
OpenAlexW4211163817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.