ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Lower synaptic density is associated with psychiatric and cognitive alterations in obesity.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal Positron Emission Tomography-Magnetic Resonance Imaging Study.Biological psychiatry · 2026Article
- Stress and synaptic density in psychosis and clinical high risk: evidence from [Translational psychiatry · 2026Article
- Synaptic density in the hippocampus of depressed patients: A quantitative electron microscopic study.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- In Vivo Positron Emission Tomography Imaging of Presynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cerebellar-Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits.Schizophrenia bulletin · 2026Article
- Neuroendocrinology and the Genetics of Obesity.Endocrinology · 2025Review
- Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats.Synapse (New York, N.Y.) · 2025Article
- SV2A is expressed in synapse subpopulations in mouse and human brain: implications for PET radiotracer studies.Wellcome open research · 2025Article
- Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation.Brain, behavior, & immunity - health · 2024Article
- Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating causality and shared genetic architecture between body mass index and cognitive function: a genome-wide cross-trait analysis and bi-directional Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.Frontiers in psychiatry · 2023Article
- Psychopathological factors and personality dimensions on dysfunctional eating behaviors in a sample of individuals with obesity.Frontiers in psychology · 2023Article
- Aberrant impulse control circuitry in obesity.Molecular psychiatry · 2022Article
- Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation.Frontiers in neuroscience · 2022Review
- Synaptic Vesicle Glycoprotein 2A: Features and Functions.Frontiers in neuroscience · 2022Review
- Uncovering the link between synaptic density and mental illness through in vivo imaging.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Obesity is a serious medical condition that often co-occurs with stress-related psychiatric disorders. It is recognized that the brain plays a key role in the (patho)physiology of obesity and that there is a bidirectional relationship between obesity and psychopathology, yet molecular mechanisms altered in obesity have not been fully elucidated. Thus, we investigated relationships between obesity and synaptic density in vivo using the radioligand [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.