ArticleCommunications biology2021
New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.Molecular psychiatry · 2026Pooled it
- Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants.Nature communications · 2026Pooled it
- Genetic Basis of the Negative Response to the Use of Triptans for the Treatment of Migraine-A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Migraine, chronic kidney disease and kidney function: observational and genetic analyses.Human genetics · 2023Pooled it
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Article
- Early-childhood temperament trajectories map onto transdiagnostic psychiatric risk.Molecular psychiatry · 2026Article
- [Gender differences in children and adolescents with migraine].Schmerz (Berlin, Germany) · 2026Review
- Integrative genetic analysis identifies shared regulation of DNA methylation and gene expression in migraine risk.The journal of headache and pain · 2026Article
- Integrative multi-omics analysis identifies endocrine-disrupting chemical-related molecular mechanisms in migraine.The journal of headache and pain · 2026Article
- Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study.Neurology. Genetics · 2026Article
- Early-childhood temperament deviations mark psychiatric risk into early adulthood.medRxiv : the preprint server for health sciences · 2026Article
- Maternal migraine and offspring ADHD: triangulating the evidence.BMC medicine · 2026Article
- Association of cognitive ability and sleep duration with headache : insights from a Chinese middle-aged and elderly population.BMC public health · 2026Article
- Diagnosing migraine from genome-wide genotype data: a machine learning analysis.Brain : a journal of neurology · 2026Article
- CGRP and Migraine: Real-World Insights and Future Therapeutic Directions.Annual review of medicine · 2026Review
- Transformer-based deep learning enhances discovery in migraine GWAS.Nature communications · 2025Article
- Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth?Pediatric neurology · 2025Article
- Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization.The journal of headache and pain · 2025Article
- Global, regional, and national burden and trends of headache disorders among children and adolescent (5-24 years old) from 1990 to 2021.BMC neurology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS1, PBRM1, and SLC25A21) specific to women. This large multiethnic migraine study provides important information that may substantially improve our understanding of the etiology of migraine susceptibility.
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Registered trials
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