ArticleScientific reports2021
Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 36 citations in OpenAlex.
- Population genomics, demography, and circum-Baltic connectivity of Early Medieval southwestern Finland.Genome biology · 2026Article
- Ancient DNA Reveals Limited Hunter-Gatherer Ancestry in the Cerny Culture (Middle Neolithic, France) Despite Hunting-Associated Practices.American journal of biological anthropology · 2026Article
- Y Chromosome Haplogroups and Susceptibility to Esophageal Squamous Cell Carcinoma: An Exploratory Association and Diagnostic Modeling Study.Molecular genetics & genomic medicine · 2026Article
- Ancient DNA reveals elite dynastic rule among Iron Age Eurasian Steppe nomads.Science advances · 2026Article
- Ancient DNA evidence for the history of the Albanians.Nature human behaviour · 2026Article
- Reconstruction of the lifeways of Central European Late Bronze Age communities using ancient DNA, isotope and osteoarchaeological analyses.Nature communications · 2026Article
- Uniparental analysis of Deep Maniot Greeks reveals genetic continuity from the pre-Medieval era.Communications biology · 2026Article
- Was descent in Neolithic and Bronze Age Europe patrilineal or bilateral?Proceedings. Biological sciences · 2025Article
- Genomic insights from a final Bronze Age community buried in a collective tumulus in an Urnfield settlement in Northeastern Iberia.Communications biology · 2025Article
- The impact of human dispersals and local interactions on the genetic diversity of coastal Papua New Guinea over the past 2,500 years.Nature ecology & evolution · 2025Article
- Article
- Article
- Article
- Interbreeding between farmers and hunter-gatherers along the inland and Mediterranean routes of Neolithic spread in Europe.Nature communications · 2024Article
- Bronze age Northern Eurasian genetics in the context of development of metallurgy and Siberian ancestry.Communications biology · 2024Article
- Article
- Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria.Cell genomics · 2024Article
- Kinship practices at the early bronze age site of Leubingen in Central Germany.Scientific reports · 2024Article
- Application of Targeted Y-Chromosomal Capture Enrichment to Increase the Resolution of Native American Haplogroup Q.Human mutation · 2024Article
- Genomic portrait and relatedness patterns of the Iron Age Log Coffin culture in northwestern Thailand.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 18 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA studies often fail to utilize the unique perspective that the NRY can yield. Here we introduce a new DNA enrichment assay, coined YMCA (Y-mappable capture assay), that targets the "mappable" regions of the NRY. We show that compared to low-coverage shotgun sequencing and 1240 k capture, YMCA significantly improves the mean coverage and number of sites covered on the NRY, increasing the number of Y-haplogroup informative SNPs, and allowing for the identification of previously undiscovered variants. To illustrate the power of YMCA, we show that the analysis of ancient Y-chromosome lineages can help to resolve Y-chromosomal haplogroups. As a case study, we focus on H2, a haplogroup associated with a critical event in European human history: the Neolithic transition. By disentangling the evolutionary history of this haplogroup, we further elucidate the two separate paths by which early farmers expanded from Anatolia and the Near East to western Europe.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.