Evidence map›Paper›PMID 34294791›Full record

ArticleScientific reports2021

Periodontitis induces endothelial dysfunction in mice.

Maria Parvaneh, Paul K Witting, Jaqueline Ku, Tala Moradi, Elif Eroglu, Ben Freedman, Greg T Sutherland, Andrew McCorkindale, Boris Guennewig, Phannaphat Choowong and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Journal of oral microbiology · 2026
    Article
  2. Article
  3. Article
  4. Therapeutic Potential of Extracellular Vesicles in Oral Inflammation.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Frontiers in immunology · 2023
    Review
  10. Article
  11. Review
  12. The impact of periodontitis on vascular endothelial dysfunction.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Maria ParvanehCharles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Paul K WittingThe Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Jaqueline KuSchool of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia.
Tala MoradiCharles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Elif ErogluCharles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Ben FreedmanCharles Perkins Centre, Heart Research Institute, The University of Sydney, Sydney, NSW, Australia.
Greg T SutherlandThe Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Andrew McCorkindaleThe Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Boris GuennewigBrain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Phannaphat ChoowongCharles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Kim Bell-AndersonThe Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Gregory CooneyThe Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Shane R ThomasSchool of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia.
Joerg EberhardCharles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. joerg.eberhard@sydney.edu.au.
University of Sydney · AUUNSW Sydney · AUThe Heart Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of periodontitis has numerous positive effects on established chronic health conditions, including cardiovascular disease and diabetes. However, ethical considerations do limit the establishment of human trials to investigate whether periodontitis promotes the early stages of chronic conditions. Therefore, the aim of this study was to investigate whether periodontitis induces endothelial dysfunction in hyperlipidemic apolipoprotein E gene-deficient (ApoE

Indexed as

AnimalsApolipoproteins EBacteriaBacteroidaceae InfectionsDisease Models, AnimalEnergy MetabolismGastrointestinal MicrobiomeGene Knockout TechniquesHyperlipidemiasMaleMicePeriodontitisPhylogenyPlaque, AtheroscleroticPorphyromonas gingivalisSequence Analysis, RNAApoe protein, mouseApolipoproteins ESerum Amyloid A ProteinTumor Necrosis Factor-alpha

Identifiers

PMID34294791
PMCPMC8298548
OpenAlexW3186416062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.