Evidence map›Paper›PMID 34294763›Full record

ArticleScientific reports2021

Neutrophils are important for the development of pro-reparative macrophages after irreversible electroporation of the liver in mice.

Maya Lopez-Ichikawa, Ngan K Vu, Amar Nijagal, Boris Rubinsky, Tammy T Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maya Lopez-IchikawaDepartment of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Ngan K VuDepartment of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Amar NijagalDepartment of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Boris RubinskyDepartment of Mechanical Engineering, University of California, Berkeley, 6124 Etcheverry Hall, Berkeley, CA, 94720, USA.
Tammy T ChangDepartment of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA. tammy.chang@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Pioneering regenerative surgery - Mechanisms of cell death and regeneration in liver treated with non-thermal irreversible electroporation (NTIRE)R21EB024135 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, TAMMY T · 2018 to 2019
$436k
NIBIB NIH HHS R21 EB024135NIDDK NIH HHS P30 DK026743NIH/NIBIB R21-EB024135
6 · The paper itself

Abstract

Irreversible electroporation (IRE) is a non-thermal tissue ablative technology that has emerging applications in surgical oncology and regenerative surgery. To advance its therapeutic usefulness, it is important to understand the mechanisms through which IRE induces cell death and the role of the innate immune system in mediating subsequent regenerative repair. Through intravital imaging of the liver in mice, we show that IRE produces distinctive tissue injury features, including delayed yet robust recruitment of neutrophils, consistent with programmed necrosis. IRE treatment converts the monocyte/macrophage balance from pro-inflammatory to pro-reparative populations, and depletion of neutrophils inhibits this conversion. Reduced generation of pro-reparative Ly6C

Indexed as

Liver RegenerationAnimalsAntigens, LyElectroporationFemaleIntravital MicroscopyLiverMacrophagesMaleMiceNeutrophilsRegenerative MedicineSOX9 Transcription FactorAntigens, LyLy-6C antigen, mouseSox9 protein, mouseSOX9 Transcription Factor

Identifiers

PMID34294763
PMCPMC8298444
OpenAlexW3185024417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.