Evidence map›Paper›PMID 34294751›Full record

ArticleScientific reports2021

Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study.

Antonin Bal, Karen Brengel-Pesce, Alexandre Gaymard, Grégory Quéromès, Nicolas Guibert, Emilie Frobert, Maude Bouscambert, Mary-Anne Trabaud, Florence Allantaz-Frager, Guy Oriol and 12 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04341142 (Assessment of Serological Techniques for Screening Patients Regarding COVID-19-COVID-SER), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04341142 naactive not recruitingnot on this map

Assessment of Serological Techniques for Screening Patients Regarding COVID-19-COVID-SER

TypeinterventionalSponsorHospices Civils de LyonRan2020 to 2026Enrolled550ConditionsCoV2 Positive CaregiversArmsSerological tests will be applied on patients blood sampling
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  5. Duration of infectious shedding of SARS-CoV-2 Omicron variant and its relation with symptoms.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 1 country.

Antonin BalLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Karen Brengel-PesceJoint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.
Alexandre GaymardLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Grégory QuéromèsCIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.
Nicolas GuibertUniversité Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Emilie FrobertLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Maude BouscambertLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Mary-Anne TrabaudLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Florence Allantaz-FragerOpen Innovation and Partnerships (OIP), bioMérieux S.A., 69280, Marcy l'Etoile, France.
Guy OriolJoint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.
Valérie CheynetJoint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.
Constance d'AubaredeUniversité Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Amélie Massardier-PiloncheryUniversité Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Marlyse BuissonInstitut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.
Julien LupoInstitut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.
Bruno PozzettoGIMAP EA 3064 (Groupe Immunité des Muqueuses et Agents Pathogènes), Université Jean Monnet, Lyon University, Saint-Etienne, France.
Pascal PoignardInstitut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.
Bruno LinaLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Jean-Baptiste FassierUniversité Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Florence MorfinLaboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
Sophie Trouillet-AssantCIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France. sophie.assant@chu-lyon.fr.
COVID-SER Study group
Université Claude Bernard Lyon 1 · FRHospices Civils de Lyon · FRInstitut Mérieux (France) · FRCentre National de la Recherche Scientifique · FRHôpital de la Croix-Rousse · FRCentre de Recherche Astrophysique de Lyon · FRCentre d'Immunologie et des Maladies Infectieuses · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p = 0.07). The proportion of HCWs with a viral load > 5.0 log

Indexed as

Health PersonnelAdultAgedAged, 80 and overCOVID-19COVID-19 Nucleic Acid TestingCOVID-19 Serological TestingFemaleHumansMaleMiddle AgedProspective StudiesSARS-CoV-2Viral LoadYoung Adult

Identifiers

PMID34294751
PMCPMC8298657
OpenAlexW3187045192

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.