ArticleNPJ Regenerative medicine2021
Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients.
Article in NPJ Regenerative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 41 citations in OpenAlex.
- Growth of Tissue-Engineered Vascular Grafts and Heart Valves As Pediatric Conduits.Annals of thoracic surgery short reports · 2026Article
- Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling.Advanced healthcare materials · 2026Review
- Optimized biomechanical design of a tissue engineered pulsatile Fontan conduit.NPJ Regenerative medicine · 2026Article
- Barriers to clinical translation of small-diameter tissue-engineered vascular grafts in peripheral reconstruction.JVS-vascular science · 2026Review
- Platelets: the first cellular responders in the foreign body response to blood-contacting biomaterials.Frontiers in immunology · 2026Review
- Artificial blood vessels-clinical development of TEVG.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts.JACC. Basic to translational science · 2025Article
- Tissue Engineered Vascular Grafts: A Quarter Century Journey of Courage, Challenge, and Persistence.JACC. Basic to translational science · 2025Article
- Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts.Journal of biomechanics · 2025Article
- FSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.Computer methods in applied mechanics and engineering · 2024Article
- Simulation-based design of bicuspidization of the aortic valve.The Journal of thoracic and cardiovascular surgery · 2024Article
- Virtual Shape-Editing of Patient-Specific Vascular Models Using Regularized Kelvinlets.IEEE transactions on bio-medical engineering · 2024Article
- Effects of cardiac growth on electrical dyssynchrony in the single ventricle patient.Computer methods in biomechanics and biomedical engineering · 2024Article
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Digital light 4D printing of bioresorbable shape memory elastomers for personalized biomedical implantation.Acta biomaterialia · 2024Article
- A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics.Computer methods in applied mechanics and engineering · 2024Article
- Development of Novel Sutureless Balloon Expandable Fetal Heart Valve Device Using Absorbable Polycaprolactone Leaflets.Annals of biomedical engineering · 2024Article
- Personalized coronary and myocardial blood flow models incorporating CT perfusion imaging and synthetic vascular trees.Npj imaging · 2024Article
- Virtual surgery to predict optimized conduit size for adult Fontan patients with 16-mm conduits.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Advances in Bioresorbable Triboelectric Nanogenerators.Chemical reviews · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
In the field of congenital heart surgery, tissue-engineered vascular grafts (TEVGs) are a promising alternative to traditionally used synthetic grafts. Our group has pioneered the use of TEVGs as a conduit between the inferior vena cava and the pulmonary arteries in the Fontan operation. The natural history of graft remodeling and its effect on hemodynamic performance has not been well characterized. In this study, we provide a detailed analysis of the first U.S. clinical trial evaluating TEVGs in the treatment of congenital heart disease. We show two distinct phases of graft remodeling: an early phase distinguished by rapid changes in graft geometry and a second phase of sustained growth and decreased graft stiffness. Using clinically informed and patient-specific computational fluid dynamics (CFD) simulations, we demonstrate how changes to TEVG geometry, thickness, and stiffness affect patient hemodynamics. We show that metrics of patient hemodynamics remain within normal ranges despite clinically observed levels of graft narrowing. These insights strengthen the continued clinical evaluation of this technology while supporting recent indications that reversible graft narrowing can be well tolerated, thus suggesting caution before intervening clinically.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.