Evidence map›Paper›PMID 34294673›Full record

ArticleNeurology international2021

SARS-CoV-2 Infection Causes Relapse of Kleine-Levin Syndrome: Case Report and Review of Literature.

Marino Marčić, Ljiljana Marčić, Barbara Marčić

Open access · goldAbstract readCase Reports
In one paragraph

Article in Neurology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Observational
  3. New-onset Kleine-Levin syndrome following COVID-19 infection: A case report.PCN reports : psychiatry and clinical neurosciences · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Relapse of Kleine-Levin Syndrome From COVID-19 Vaccine: Causal or Coincidence?Journal of clinical neurology (Seoul, Korea) · 2023
    Article
  8. An Update on Kleine-Levin Syndrome.Current sleep medicine reports · 2023
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marino MarčićDepartment of Neurology, University Hospital Center Split, Spinčićeva1, 21000 Split, Croatia.ORCID 0000-0003-2235-7468
Ljiljana MarčićDepartment of Radiology, Polyclinic Medikol, 21000 Split, Croatia.
Barbara MarčićDepartment of Histology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.
University of Mostar · BAUniversity of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent episodes of hypersomnia, hypersexuality, compulsive eating, behavioral and cognitive disturbances, are the basic clinical features of Kleine-Levin syndrome (KLS). Our case report describes a patient who was diagnosed with KLS at the age of 20. With appropriate therapy, the disease had a satisfactory course until patient had a moderate form of SARS-CoV-2 infection, which led to a significant exacerbation of all symptoms. SARS-CoV-2 virus can cause almost any neurological disease, and relapse of KLS is another evidence of neurotropicity of the virus.

Indexed as

hyperphagiahypersomniaKleine-LevinSARS-CoV-2

Identifiers

PMID34294673
PMCPMC8299328
OpenAlexW3184095723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.