ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2021
Significant Shortening of Leukocyte Telomere Length in Korean Patients with Bipolar Disorder 1.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder.Biological psychiatry global open science · 2023Article
- Leukocyte telomere length and bipolar disorder risk: evidence from Mendelian randomization analysis.PeerJ · 2023Article
- Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Review
- To study childhood trauma in patients with bipolar affective disorder and its association with leucocyte telomere length.Medical journal, Armed Forces IndiaArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTelomere shortening has been seen in major psychiatric disorders, including major depressive disorder. However, only a few small studies have examined this in bipolar disorder (BD). We compared the telomere length in patients with BD1 or BD2 with that in matched healthy controls.
methodsWe included 215 patients with BD (128 BD1, 87 BD2) and 204 age- and sex-matched healthy controls. Relative telomere length was determined by quantitative polymerase chain reaction. The patients and controls were compared separately for age groups, sex, and BD subgroups (BD1 and BD2).
resultsWe found significant telomere shortening in patients with BD1 (p < 0.001), but not in patients with BD2. In male patients with BD1, the 30-39 year age group had significant shortening of telomere length than controls (p = 0.01). Female patients with BD1 in the 19-29-year age group had significantly shortened telomeres compared to the controls (p < 0.01).
conclusionOur results suggest a significant reduction in telomere length in BD1. Telomere shortening would be a potential biomarker for BD.
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