Evidence map›Paper›PMID 34294086›Full record

ArticleAIDS research and therapy2021

Persons living with HIV in sero-discordant partnerships experience improved HIV care engagement compared with persons living with HIV in sero-concordant partnerships: a cross-sectional analysis of four African countries.

Domonique M Reed, Allahna L Esber, Trevor A Crowell, Kavitha Ganesan, Hannah Kibuuka, Jonah Maswai, John Owuoth, Emmanuel Bahemana, Michael Iroezindu, Julie A Ake and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. "AIDS care · 2026
    Article
  2. Article
  3. Article
  4. Psychosocial support for HIV serodiscordant couples.Health psychology and behavioral medicine · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Domonique M ReedDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Suite 700, New York, NY, 10032, USA. dmr2204@cumc.columbia.edu.ORCID 0000-0002-4593-6860
Allahna L EsberU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
Trevor A CrowellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
Kavitha GanesanDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Suite 700, New York, NY, 10032, USA.
Hannah KibuukaMakerere University-Walter Reed Project, Kampala, Uganda.
Jonah MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
John OwuothU.S. Army Medical Research Directorate - Africa, Kisumu, Kenya.
Emmanuel BahemanaU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
Michael IroezinduU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
Julie A AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
Christina S PolyakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, New York, MD, USA.
AFRICOS Study Team
Henry M. Jackson Foundation · USWalter Reed Army Institute of Research · USMakerere University Walter Reed Project · UGUnited States Army Medical Research Directorate - Africa · KE

Funding

U.S. President's Emergency Plan for AIDS Relief W81XWH-11-2-0174
6 · The paper itself

Abstract

backgroundPersons living with HIV (PLWH) who are members of sero-discordant and sero-concordant relationships may experience psychological stressors or motivators that affect HIV care. We assessed the association between sero-discordance status, antiretroviral therapy (ART) uptake, and viral suppression in the African Cohort Study (AFRICOS).

methodsAFRICOS enrolls PLWH and HIV-uninfected individuals at 12 sites in Uganda, Kenya, Tanzania, and Nigeria. At enrollment, we determined ART use through self-report. Viral suppression was defined as HIV RNA < 1000 copies/mL. We analyzed PLWH who were index participants within two types of sexual dyads: sero-discordant or sero-concordant. Binomial regression models were used to estimate prevalence ratios (PRs) and 95% confidence intervals (95% CIs) for factors associated with ART use and viral suppression at study enrollment.

resultsFrom January 2013 through March 2018, 223 index participants from sero-discordant dyads and 61 from sero-concordant dyads were enrolled. The majority of the indexes were aged 25-34 years (50.2%), female (53.4%), and married (96.5%). Sero-discordant indexes were more likely to disclose their status to partners compared with sero-concordant indexes (96.4% vs. 82.0%, p < 0.001). After adjustment, sero-discordant index participants were more likely to be on ART (aPR 2.8 [95% CI 1.1-6.8]), but no more likely to be virally suppressed. Results may be driven by unique psycho-social factors and global implementation of treatment as prevention.

conclusionsPLWH in sero-discordant sexual partnerships demonstrated improved uptake of ART compared with those in sero-concordant partnerships. Interventions are needed to increase care engagement by individuals in sero-concordant relationships to improve HIV outcomes.

Indexed as

HIV InfectionsCohort StudiesCross-Sectional StudiesFemaleHumansSexual BehaviorSexual PartnersUgandaART uptakeHIV care continuumSero-discordant relationshipSub-Saharan AfricaViral load

Identifiers

PMID34294086
PMCPMC8296539
OpenAlexW3186799483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.