ArticleBMC pulmonary medicine2021
Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study.
Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association Between Pulmonary Function, Respiratory Muscle Strength and Cognitive Function in Chinese Community-Dwelling Older Adults.Clinical interventions in aging · 2026Article
- Article
- Multiomics: Two-Sample, Bidirectional, Multivariate and Mediated Mendelian Randomization Analysis of Allergic Rhinitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Construction and evaluation of nomogram for risk prediction of cognitive impairment in chronic obstructive pulmonary disease comorbidity.BMC psychology · 2025Article
- Diagnosis of chronic obstructive pulmonary disease (COPD) in older patients : Consensus statement of the Working Group on Pneumology in Older Patients.Zeitschrift fur Gerontologie und Geriatrie · 2025Review
- Exploring the Relationship Between Immune Cells and Chronic Kidney Disease by Mendelian Randomization, Colocalization Analysis, and SMR.Mediators of inflammation · 2025Article
- Association between pulmonary ventilation function and cognitive function among middle-aged and older adults: an observational study from Southwest China.BMC pulmonary medicine · 2024Observational
- Association of household chemicals use with cognitive function among Chinese older adults.Heliyon · 2024Article
- Clinical trajectories preceding incident dementia up to 15 years before diagnosis: a large prospective cohort study.Molecular psychiatry · 2024Article
- Outcomes and Hospital Service Use Among Patients With COPD in a Nurse- and Allied Health-Led Clinic.JAMA health forum · 2024Article
- Association of low attenuation area scores with pulmonary function and clinical prognosis in patients with chronic obstructive pulmonary disease.Open life sciences · 2024Article
- Lung development genes, adult lung function and cognitive traits.Brain communications · 2024Article
- Causal relationship between the immune cells and ankylosing spondylitis: univariable, bidirectional, and multivariable Mendelian randomization.Frontiers in immunology · 2024Article
- Lung function and cognitive ability in children: a UK birth cohort study.BMJ open respiratory research · 2023Article
- Major depressive disorder plays a vital role in the pathway from gastroesophageal reflux disease to chronic obstructive pulmonary disease: a Mendelian randomization study.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundObservational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options are currently very limited. Attention has therefore focused on identifying modifiable risk factors to prevent cognitive decline and preserve cognition. Our objective was to determine if lung function or risk of COPD causes reduced cognitive function using Mendelian randomization (MR).
methodsSingle nucleotide polymorphisms from genome wide association studies of lung function and COPD were used as exposures. We examined their effect on general cognitive function in a sample of 132,452 individuals. We then performed multivariable MR (MVMR), examining the effect of lung function before and after conditioning for covariates.
resultsWe found only weak evidence that reduced lung function (Beta - 0.002 (SE 0.02), p-value 0.86) or increased liability to COPD (- 0.008 (0.008), p-value 0.35) causes lower cognitive function. MVMR found both reduced FEV
conclusionWe did not find evidence that reduced lung function or COPD causes reduced cognitive function. Previous observational studies are probably affected by residual confounding. Research efforts should focus on shared risk factors for reduced lung function and cognition, rather than lung function alone as a modifiable risk factor.
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