Evidence map›Paper›PMID 34294013›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase.

Tereza Cristina Santos Evangelista, Óscar López, Sabrina Baptista Ferreira, José G Fernández-Bolaños, Magne O Sydnes, Emil Lindbäck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tereza Cristina Santos EvangelistaDepartment of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Óscar LópezDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Sabrina Baptista FerreiraDepartment of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
José G Fernández-BolañosDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Magne O SydnesDepartment of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Emil LindbäckDepartment of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold

Indexed as

Drug DevelopmentAcetylcholinesteraseAnimalsCholinesterase InhibitorsDose-Response Relationship, DrugElectrophorusMolecular StructureStructure-Activity RelationshipTacrineAcetylcholinesteraseCholinesterase InhibitorsTacrineAcetylcholinesteraseCuAACmultivalent inhibition potencymultivalent interactionstacrine

Identifiers

PMID34294013
PMCPMC8317962

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.