Evidence map›Paper›PMID 34293939›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis.

Aditya Rayasam, Amandine Jullienne, Tetyana Chumak, Joel Faustino, Jenny Szu, Mary Hamer, C Joakim Ek, Carina Mallard, Andre Obenaus, Zinaida S Vexler

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Aditya RayasamDepartment of Neurology, University California San Francisco, San Francisco, CA, USA.
Amandine JullienneDepartment of Pediatrics, University of California Irvine, Irvine, CA, USA.
Tetyana ChumakDepartment of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Joel FaustinoDepartment of Neurology, University California San Francisco, San Francisco, CA, USA.
Jenny SzuDepartment of Pediatrics, University of California Irvine, Irvine, CA, USA.
Mary HamerDepartment of Pediatrics, University of California Irvine, Irvine, CA, USA.
C Joakim EkDepartment of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Carina MallardDepartment of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Andre ObenausDepartment of Pediatrics, University of California Irvine, Irvine, CA, USA.
Zinaida S VexlerDepartment of Neurology, University California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6491-1562
University of California, Irvine · USUniversity of California, San Francisco · USUniversity of Gothenburg · SE

Funding

Neonatal Stroke: The Role of Microglia-derived Extracellular VesiclesR01NS044025 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VEXLER, ZINAIDA S · 2002 to 2023
$7.7M
Childhood stroke: effects of infection-induced arteriopathiesR01NS103483 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zinaida S Vexler · 2018 to 2026
$3.7M
Macrophages as modulators of repair after neonatal strokeR01NS076726 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VEXLER, ZINAIDA S · 2012 to 2016
$1.8M
NINDS NIH HHS R01 NS044025NINDS NIH HHS R01 NS076726NINDS NIH HHS R01 NS103483
6 · The paper itself

Abstract

Stroke is among the top ten causes of death in children but has received disproportionally little attention. Cerebral arteriopathies account for up to 80% of childhood arterial ischemic stroke (CAIS) cases and are strongly predictive of CAIS recurrence and poorer outcomes. The underlying mechanisms of sensitization of neurovasculature by viral infection are undefined. In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks. First, using an array of

Indexed as

Leukocyte ElastaseStrokeAnimalsBlood-Brain BarrierCerebral ArteriesChildExtracellular TrapsHumansMiceMice, TransgenicPoly I-CSignal TransductionTight JunctionsToll-Like Receptor 3Leukocyte ElastasePoly I-CTLR3 protein, mouseToll-Like Receptor 3blood-brain barrierNeutrophil elastaseneutrophil extracellular trapssivelestattoll-like receptor 3

Identifiers

PMID34293939
PMCPMC8669290
OpenAlexW3183411645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.