Evidence map›Paper›PMID 34293641›Full record

ArticleJournal of infection and public health2021

SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals.

Andrea Lombardi, Dario Consonni, Massimo Oggioni, Patrizia Bono, Sara Uceda Renteria, Alessandra Piatti, Angela C Pesatori, Silvana Castaldi, Antonio Muscatello, Luciano Riboldi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of infection and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Vaccination Open Day: A Cross-Sectional Study on the 2023 Experience in Lombardy Region, Italy.International journal of environmental research and public health · 2024
    Article
  2. Increased Risk of Thyroid Eye Disease Following Covid-19 Vaccination.The Journal of clinical endocrinology and metabolism · 2024
    Article
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  17. COVID-19: an outbreak in a nursing home in spring 2021.Acta bio-medica : Atenei Parmensis · 2021
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  18. Article
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  20. Antibody Responses of SARS-CoV-2 Vaccines amongst Health Care Workers in a Tertiary Care Hospital in Tripura, India: A Cross-Sectional Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Andrea LombardiInfectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. Electronic address: andrea.lombardi@unimi.it.
Dario ConsonniEpidemiology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Massimo OggioniClinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.
Patrizia BonoClinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.
Sara Uceda RenteriaClinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.
Alessandra PiattiMedical Direction, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Angela C PesatoriEpidemiology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
Silvana CastaldiDepartment Biomedical Sciences for Health, University of Milan, Milan, Italy; Quality and Internal Audit Privacy Unit, University of Milan, Milan, Italy.
Antonio MuscatelloInfectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Luciano RiboldiOccupational Health Unit, Foundation IRCCS Ca' Granda Ospedale MaggiorePoliclinico, Milan, Italy.
Ferruccio CeriottiClinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.
Alessandra BanderaInfectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.
Andrea GoriInfectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed the antibody titres in a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 to assess the influence of a previous infection on them. We stratified the results according to the individual history of nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs the highest titres were recorded among those infected more than 6 months before vaccination, independently of symptoms, followed by those infected less than 6 months before vaccination, especially in those with symptoms, and by uninfected HCWs. Vaccination with BNT162b2 can boost immunity acquired through infection, particularly in those infected more than 6 months before vaccination.

Indexed as

COVID-19SARS-CoV-2BNT162 VaccineCOVID-19 VaccinesHumansVaccinationBNT162 VaccineCOVID-19 VaccinesBNT162b2COVID-19Healthcare workersVaccination

Identifiers

PMID34293641
PMCPMC8285930
OpenAlexW3186179544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.