Trial reportAnnals of oncology : official journal of the European Society for Medical Oncology2021
Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 80702 phase III study (Alliance)
Trial report in Annals of oncology : official journal of the European Society for Medical Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Tumour deposits are associated with worse survival than extranodal extension; a network meta-analysis on tumour nodules in colorectal cancer.Histopathology · 2025Pooled it
- Development and validation of a nomogram for preoperative prediction of tumor deposits in colorectal cancer.World journal of gastroenterology · 2023Trial
- Tumour deposits in colorectal carcinoma are associated with immune evasion and dose-dependent adverse prognosis beyond nodal status.British journal of cancer · 2026Article
- Prognostic importance of tumour deposits with and without concurrent lymph node metastases in patients with stage III colon cancer.BJS open · 2026Article
- Independent prognostic value of tumor deposits in stage III colorectal cancer: a large-scale systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- Do Tumor Deposits Demand More? Association of Chemotherapy Regimen Intensity with Survival Outcomes in N1 Colon Cancer Patients with Tumor Deposits.Annals of surgical oncology · 2026Article
- A Machine Learning Framework for Prognostic Modeling in Stage III Colon Cancer.Journal of clinical medicine · 2026Article
- Article
- MRI-Based Differentiation of Tumor Deposits and Lymph Node Metastases in Rectal Cancer: A Systematic Review of Diagnostic Performance.Journal of clinical medicine · 2026Review
- Article
- MRI-derived radiomics for risk stratification of tumor deposits in rectal cancer: a dual-center study.Insights into imaging · 2026Article
- Mass spectrometry-based multi-omics analysis elucidates immune microenvironmental characteristics and the risk of distant metastasis in N1c colorectal cancer.Frontiers in immunology · 2026Article
- Prognostic value of tumor deposits and their different response to neoadjuvant therapy in locally advanced rectal cancer.PloS one · 2026Article
- Prognostic value of a modified lymph node ratio for combined colorectal cancer tumour deposits: a population-based study.Frontiers in oncology · 2026Article
- Stratifying prognosis in stage III colorectal cancer patients: the role of tumor deposits and lymph node ratio.Translational cancer research · 2025Article
- Complete Mesocolic Excision for Colon Cancer: Insight into Potential Mechanisms of Oncologic Benefit.Cancers · 2025Review
- Prognostic impact and independent significance of tumor deposits in early-stage colon cancer: a population-based cohort study.International journal of colorectal disease · 2025Article
- Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study.Scientific reports · 2025Article
- Discriminating Tumor Deposits From Metastatic Lymph Nodes in Rectal Cancer: A Pilot Study Utilizing Dynamic Contrast-Enhanced MRI.Korean journal of radiology · 2025Article
- Prognostic value of tumor deposits and positive lymph nodes in colorectal cancer surgery: improved staging for long-term prognosis.BMC gastroenterology · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 16 institutions in 3 countries.
Funding
Abstract
backgroundIn colon cancer, tumor deposits (TD) are considered in assigning prognosis and staging only in the absence of lymph node metastasis (i.e. stage III pN1c tumors). We aimed to evaluate the prognostic value of the presence and the number of TD in patients with stage III, node-positive colon cancer. PATIENTS AND
methodsAll participants from the CALGB/SWOG 80702 phase III trial were included in this post hoc analysis. Pathology reports were reviewed for the presence and the number of TD, lymphovascular and perineural invasion. Associations with disease-free survival (DFS) and overall survival (OS) were evaluated by multivariable Cox models adjusting for sex, treatment arm, T-stage, N-stage, lymphovascular invasion, perineural invasion and lymph node ratio.
resultsOverall, 2028 patients were included with 524 (26%) TD-positive and 1504 (74%) TD-negative tumors. Of the TD-positive patients, 80 (15.4%) were node negative (i.e. pN1c), 239 (46.1%) were pN1a/b (<4 positive lymph nodes) and 200 (38.5%) were pN2 (≥4 positive lymph nodes). The presence of TD was associated with poorer DFS [adjusted hazard ratio (aHR) = 1.63, 95% CI 1.33-1.98] and OS (aHR = 1.59, 95% CI 1.24-2.04). The negative effect of TD was observed for both pN1a/b and pN2 groups. Among TD-positive patients, the number of TD had a linear negative effect on DFS and OS. Combining TD and the number of lymph node metastases, 104 of 1470 (7.1%) pN1 patients were re-staged as pN2, with worse outcomes than patients confirmed as pN1 (3-year DFS rate: 65.4% versus 80.5%, P = 0.0003; 5-year OS rate: 87.9% versus 69.1%, P = <0.0001). DFS was not different between patients re-staged as pN2 and those initially staged as pN2 (3-year DFS rate: 65.4% versus 62.3%, P = 0.4895).
conclusionCombining the number of TD and the number of lymph node metastases improved the prognostication accuracy of tumor-node-metastasis (TNM) staging.
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