ArticleThe Journal of pediatrics2021
Influenza-Associated Neurologic Complications in Hospitalized Children.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Immunogenicity and safety of 1 versus 2 doses of quadrivalent-inactivated influenza vaccine in children aged 3-8 years with or without previous influenza vaccination histories.Human vaccines & immunotherapeutics · 2025Trial
- [Clinical features and prognosis of influenza-associated encephalopathy in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Decoding the lung-brain axis in influenza: from pulmonary infection to central nervous system injury.Journal of neuroinflammation · 2026Review
- Pathogens of the human central nervous system-the major viral pathogens.Journal of neurovirology · 2026Review
- Article
- Epidemiological characteristics analysis of childhood influenza A virus infections in Hebei, China (2020-2024).Frontiers in pediatrics · 2026Article
- Burden and Clinical Characteristics of Influenza and Its Complications in Children Across Multiple Epidemic Seasons.Viruses · 2025Observational
- Influenza-Related Encephalopathy in Children: Epidemiology and Literature Review from a Tertiary Hospital in Northern Italy (Winter 2023-2024).Pathogens (Basel, Switzerland) · 2025Review
- Elevated D-dimer on admission may predict poor prognosis in childhood influenza associated encephalopathy.Scientific reports · 2025Article
- Severe Neurological Complications With Influenza in Vietnamese Children.Influenza and other respiratory viruses · 2024Article
- Acute necrotizing encephalopathy in adult patients with influenza: a case report and review of the literature.BMC infectious diseases · 2024Review
- Review
- Characteristics and outcome of influenza-associated encephalopathy/encephalitis among children in China.Clinics (Sao Paulo, Brazil) · 2024Article
- Complications of the Central Nervous System in Pediatric Patients With Common Cold Coronavirus Infection During 2014-2019.Journal of Korean medical science · 2023Article
- A Characterization of Neurology Consults for Inpatients with SARS-CoV-2 Infection Compared to Other Respiratory Viruses.Neurology international · 2023Article
- Influenza in Children and Adolescents: Epidemiology, Management, and Prevention.Pediatrics in review · 2023Article
- Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing.Viruses · 2023Article
- Severe Influenza Virus and Respiratory Syncytial Virus Infections in Intensive Care Over the Last 15 Years.Cureus · 2023Article
- Article
- Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro.Virology journal · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza and to identify associated clinical, epidemiologic, and virologic factors. STUDY
designThis was an historical cohort study of children aged 0.5-18.0 years old hospitalized between 2010 and 2017 with laboratory-confirmed influenza. Children with immune compromise or a positive test due to recent receipt of live virus vaccine or recently resolved illness were excluded. Influenza-associated neurologic complications were defined as new-onset neurologic signs/symptoms during acute influenza illness without another clear etiology.
resultsAt least 1 influenza-associated neurologic complication was identified in 10.8% (95% CI 9.1-12.6%, n = 131 of 1217) of hospitalizations with laboratory-confirmed influenza. Seizures (n = 97) and encephalopathy (n = 44) were the most commonly identified influenza-associated neurologic complications, although an additional 20 hospitalizations had other influenza-associated neurologic complications. Hospitalizations with influenza-associated neurologic complications were similar in age and influenza type (A/B) to those without. Children with a pre-existing neurologic diagnosis (n = 326) had a greater proportion of influenza-associated neurologic complications compared with those without (22.7% vs 6.4%, P < .001). Presence of a pre-existing neurologic diagnosis (aOR 4.6, P < .001), lack of seasonal influenza vaccination (aOR 1.6, P = .020), and age ≤5 years (aOR 1.6, P = .017) were independently associated with influenza-associated neurologic complications.
conclusionsInfluenza-associated neurologic complications are common in children hospitalized with influenza, particularly those with pre-existing neurologic diagnoses. A better understanding of the epidemiology and factors associated with influenza-associated neurologic complications will direct future investigation into potential neuropathologic mechanisms and mitigating strategies. Vaccination is recommended and may help prevent influenza-associated neurologic complications in children.
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