Evidence map›Paper›PMID 34293288›Full record

ArticleNeuron2021

Replenishing our mind orchards: Enhancing myelin renewal to rescue cognition in Alzheimer's disease.

Niamh B McNamara, Veronique E Miron

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Niamh B McNamaraCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK; United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, UK; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
Veronique E MironCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK; United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, UK; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK. Electronic address: V.Miron@ed.ac.uk.

Funding

Medical Research Council MR/M020827/1Medical Research Council MR/N022556/1Medical Research Council MR/V031260/1
6 · The paper itself

Abstract

In this issue of Neuron, Chen et al. (2021) reveal dynamic changes in myelin in an Alzheimer's disease (AD) mouse model. Enhancing myelination genetically or pharmacologically improves cognition in this model, supporting myelin as a therapeutic target for AD.

Indexed as

Alzheimer DiseaseAnimalsCognitionDisease Models, AnimalMiceMyelin SheathNeurons

Identifiers

PMID34293288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.