ArticleThe American journal of clinical nutrition2022
Long-term dietary protein intake and subjective cognitive decline in US men and women.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Sustainable dietary recommendations for the Spanish population.European journal of clinical nutrition · 2026Pooled it
- Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies.Aging clinical and experimental research · 2024Pooled it
- Nutritional regulation of gut-brain immune crosstalk across the lifespan.Gut microbes · 2026Review
- Protein Consumption and Cognitive Health in Aging: Associations with Sarcopenia and Dietary Options, a Narrative Review.Nutrients · 2026Review
- Long-term adherence and changes in the Mediterranean and MIND diets in relation to dementia risk and cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of midlife macronutrient and mineral intake with subjective cognitive complaints in a prospective cohort of women.European journal of nutrition · 2026Article
- Relevance and Safe Utilization of Amino Acids in Supplements for Human Nutrition: Lessons from Clinical and Preclinical Studies.Nutrients · 2026Review
- How the Intake of Pulses May Impact Metabolic Disorders and Dementia Risk: A Narrative Review.Nutrients · 2025Review
- The association between total, animal-based, and plant-based protein intake and cognitive decline in older adults.European journal of nutrition · 2025Article
- Adhering to Healthy Dietary Patterns Prevents Cognitive Decline of Older Adults with Sarcopenia: The Mr. OS and Ms. OS Study.Nutrients · 2025Article
- Food inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food?Journal of advanced research · 2025Article
- Evaluating dietary quality and dietary inflammatory potential in cognitive impairment patients in China.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dietary Factors and Cognitive Function: with a Focus on Subjective Cognitive Decline.Current nutrition reports · 2025Review
- Article
- Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults.Neurology · 2025Article
- Subjective cognitive decline-a neglected but preventable public health concern: development and validation of a risk prediction model for subjective cognitive decline in older adults: a cross-sectional survey study from Anhui Province in eastern China.Frontiers in public health · 2025Article
- Dietary adherence and cognitive performance in older adults: insights from a nationwide survey in China.Frontiers in nutrition · 2025Article
- The Protein Link: Leveraging Precision Nutrition to Shape Cardiovascular Wellness.Precision nutrition · 2024Article
- Association between diet protein score comprising plants to animal protein ratio and body composition in an Iranian population.Scientific reports · 2024Article
- Association of Low Protein-to-Carbohydrate Energy Ratio with Cognitive Impairment in Elderly Type 2 Diabetes Patients.Nutrients · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDiet is one of the modifiable risk factors for cognitive decline. However, studies on dietary protein intake and cognitive decline have remained limited and inconclusive.
objectivesIn this study, we aimed to investigate the associations between long-term dietary protein intake and subsequent subjective cognitive decline (SCD).
methodsWe included 49,493 women from the Nurses' Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). For the NHS, average dietary intake was calculated from 7 repeated semi-quantitative FFQs (SFFQs), and SCD was assessed in 2012 and 2014. For the HPFS, average dietary intake was calculated from 5 repeated SFFQs, and SCD was assessed in 2008 and 2012. Poisson regression was used to examine the associations between dietary protein, amino acids, and various protein food sources with subsequent SCD.
resultsHigher protein intake compared with total carbohydrates was associated with lower odds of SCD. When substituting 5% energy from protein for the equivalent percentage of energy from total carbohydrates, the pooled multivariable-adjusted ORs (95% CIs) were 0.89 (0.85, 0.94) for total protein, 0.89 (0.84, 0.94) for animal protein, and 0.74 (0.62, 0.88) for plant protein. When substituting 5% of energy from animal protein with plant protein, the OR was 0.84 (95% CI: 0.72, 0.97). For protein food sources, higher intakes of beans/legumes, fish, and lean poultry were significantly associated with lower odds of SCD, but higher intake of hotdogs was associated with higher odds of SCD.
conclusionsHigher protein intake was associated with lower odds of SCD when compared isocalorically with carbohydrate. Plant protein sources were also associated with lower odds when compared with animal protein sources. Our findings suggest that adequate protein intake, and choices of protein sources could play a role in the maintenance of cognition and should be studied further.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.