ArticlePLoS neglected tropical diseases2021
Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- Differential resistance of heat shock proteins (HSP70 and HSP90) in Anopheles culicifacies mosquitoes with respect to variations in temperature in India.Molecular biology reports · 2026Article
- The Links Between Dengue Virus, Climate and Climate Change.Current topics in microbiology and immunology · 2026Review
- Plasticity in climate change responses.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Repeated thermal stress exposure inmSphere · 2025Article
- Thermal adaptation inProceedings. Biological sciences · 2025Article
- Effect of prolonged dehydration stress on the vector competence ofbioRxiv : the preprint server for biology · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Article
- Article
- Evolutionary adaptation under climate change:Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Evolutionary adaptation under climate change:bioRxiv : the preprint server for biology · 2024Article
- Stable introduction of Wolbachia wPip into invasive Anopheles stephensi for potential malaria control.PLoS neglected tropical diseases · 2024Article
- Insect-microbe interactions and their influence on organisms and ecosystems.Ecology and evolution · 2024Review
- High temperatures and low humidity promote the occurrence of microsporidians (Microsporidia) in mosquitoes (Culicidae).Parasites & vectors · 2024Article
- Dehydration stress and Mayaro virus vector competence inJournal of virology · 2023Article
- Assessing the Relationship between Annual Surface Temperature Changes and the Burden of Dengue: Implications for Climate Change and Global Health Outcomes.Tropical medicine and infectious disease · 2023Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Assessing the role of family level variation and heat shock gene expression in the thermal stress response of the mosquitoPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mosquito Aedes aegypti is the primary vector of many disease-causing viruses, including dengue (DENV), Zika, chikungunya, and yellow fever. As consequences of climate change, we expect an increase in both global mean temperatures and extreme climatic events. When temperatures fluctuate, mosquito vectors will be increasingly exposed to temperatures beyond their upper thermal limits. Here, we examine how DENV infection alters Ae. aegypti thermotolerance by using a high-throughput physiological 'knockdown' assay modeled on studies in Drosophila. Such laboratory measures of thermal tolerance have previously been shown to accurately predict an insect's distribution in the field. We show that DENV infection increases thermal sensitivity, an effect that may ultimately limit the geographic range of the virus. We also show that the endosymbiotic bacterium Wolbachia pipientis, which is currently being released globally as a biological control agent, has a similar impact on thermal sensitivity in Ae. aegypti. Surprisingly, in the coinfected state, Wolbachia did not provide protection against DENV-associated effects on thermal tolerance, nor were the effects of the two infections additive. The latter suggests that the microbes may act by similar means, potentially through activation of shared immune pathways or energetic tradeoffs. Models predicting future ranges of both virus transmission and Wolbachia's efficacy following field release may wish to consider the effects these microbes have on host survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.