ArticlePLoS genetics2021
Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Genomic diversity, inbreeding, and selection signatures in duroc, landrace, and yorkshire pigs from a long-term closed breeding system.Journal of applied genetics · 2026Article
- Landscape Genomics Reveals Divergent Adaptation Modes and Predicts Climate Vulnerability in Xinjiang Indigenous Sheep.Animals : an open access journal from MDPI · 2026Article
- Methods to detect selection history in a population under ongoing directional selection.Genetics · 2026Article
- Population Structure Analysis and Candidate Gene Screening for Twinning Trait in Simmental Cattle.Animals : an open access journal from MDPI · 2026Article
- A comprehensive genomic characterization of Nellore cattle.BMC genomics · 2026Article
- Management practices of five U.S. sheep breeds: insights from a producer survey.Translational animal science · 2026Article
- Integrating whole-genome resequencing data reveals adaptive selection signatures in sheep populations under extreme environments.BMC genomics · 2025Article
- Applying Genomic Offsets to Breeding Programmes: Bridging Evolutionary Insights With Practical Applications.Evolutionary applications · 2025Article
- Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model.Animal genetics · 2025Article
- Changes in allele frequencies and genetic architecture due to selection in two pig populations.Genetics, selection, evolution : GSE · 2024Article
- Insights into trait-association of selection signatures and adaptive eQTL in indigenous African cattle.BMC genomics · 2024Article
- Impact of Heat Stress on Oocyte Developmental Competence and Pre-Implantation Embryo Viability in Cattle.Animals : an open access journal from MDPI · 2024Review
- Genotype-by-environment interactions and local adaptation shape selection in the US National Chip Processing Trial.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Uncovering the architecture of selection in twoEvolutionary applications · 2024Article
- Analysis of polygenic selection in purebred and crossbred pig genomes using generation proxy selection mapping.Genetics, selection, evolution : GSE · 2023Article
- Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics.Human genetics · 2023Review
- Clustering climate and management practices to define environmental challenges affecting gastrointestinal parasitism in Katahdin sheep.Journal of animal science · 2023Article
- Genomic assessment reveals signal of adaptive selection in populations of the Spotted rose snapperPeerJ · 2023Article
- Stacked kinship CNN vs. GBLUP for genomic predictions of additive and complex continuous phenotypes.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selection on complex traits can rapidly drive evolution, especially in stressful environments. This polygenic selection does not leave intense sweep signatures on the genome, rather many loci experience small allele frequency shifts, resulting in large cumulative phenotypic changes. Directional selection and local adaptation are changing populations; but, identifying loci underlying polygenic or environmental selection has been difficult. We use genomic data on tens of thousands of cattle from three populations, distributed over time and landscapes, in linear mixed models with novel dependent variables to map signatures of selection on complex traits and local adaptation. We identify 207 genomic loci associated with an animal's birth date, representing ongoing selection for monogenic and polygenic traits. Additionally, hundreds of additional loci are associated with continuous and discrete environments, providing evidence for historical local adaptation. These candidate loci highlight the nervous system's possible role in local adaptation. While advanced technologies have increased the rate of directional selection in cattle, it has likely been at the expense of historically generated local adaptation, which is especially problematic in changing climates. When applied to large, diverse cattle datasets, these selection mapping methods provide an insight into how selection on complex traits continually shapes the genome. Further, understanding the genomic loci implicated in adaptation may help us breed more adapted and efficient cattle, and begin to understand the basis for mammalian adaptation, especially in changing climates. These selection mapping approaches help clarify selective forces and loci in evolutionary, model, and agricultural contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.