ArticlePLoS biology2021
Predicting learning and achievement using GABA and glutamate concentrations in human development.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Metabolic biomarkers of treatment-resistant schizophrenia and cognitive correlates: insights from a machine learning.Molecular psychiatry · 2026Article
- Glutamatergic signaling underlies brain structural organization for mathematical and reading abilities in children.Nature communications · 2026Article
- Latent Neurocognitive Mechanisms Underlying Quantity Discrimination in Children with and without Mathematical Learning Disabilities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Rethinking excitation/inhibition balance in the human brain.Nature reviews. Neuroscience · 2025Article
- Functional connectivity and GABAergic signaling modulate the enhancement effect of neurostimulation on mathematical learning.PLoS biology · 2025Article
- Personalized deep neural networks reveal mechanisms of math learning disabilities in children.Science advances · 2025Article
- Aperiodic component of EEG power spectrum and cognitive performance are modulated by education in aging.Scientific reports · 2024Article
- Digital twins for understanding mechanisms of learning disabilities: Personalized deep neural networks reveal impact of neuronal hyperexcitability.bioRxiv : the preprint server for biology · 2024Article
- Receive, Retain and Retrieve: Psychological and Neurobiological Perspectives on Memory Retrieval.Integrative psychological & behavioral science · 2024Article
- Article
- Human neuronal excitation/inhibition balance explains and predicts neurostimulation induced learning benefits.PLoS biology · 2023Article
- The moderating role of recreational substance use in the association of Mediterranean diet with academic performance among adolescents.Scientific reports · 2023Article
- A comprehensive guide to MEGA-PRESS for GABA measurement.Analytical biochemistry · 2023Review
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
- Predicting Math Ability Using Working Memory, Number Sense, and Neurophysiology in Children and Adults.Brain sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning and plasticity. What is currently unknown is how this knowledge translates to real-life complex cognitive abilities that emerge slowly and how the link between these neurotransmitters and human learning and plasticity is shaped by development. While some have suggested a generic role of glutamate and GABA in learning and plasticity, others have hypothesized that their involvement shapes sensitive periods during development. Here we used a cross-sectional longitudinal design with 255 individuals (spanning primary school to university) to show that glutamate and GABA in the intraparietal sulcus explain unique variance both in current and future mathematical achievement (approximately 1.5 years). Furthermore, our findings reveal a dynamic and dissociable role of GABA and glutamate in predicting learning, which is reversed during development, and therefore provide novel implications for models of learning and plasticity during childhood and adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.