Evidence map›Paper›PMID 34292932›Full record

ReviewPLoS neglected tropical diseases2021

Addressing antimicrobial resistance by improving access and quality of care-A review of the literature from East Africa.

Kathrin Loosli, Alicia Davis, Adrian Muwonge, Tiziana Lembo

Abstract readReview
In one paragraph

Review in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. The Use of CHROMIDAntibiotics (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Review
  16. Supply-chain factors and antimicrobial stewardship.Bulletin of the World Health Organization · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Multidrug Resistance: The Growing Menace in PICU.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kathrin LoosliThe Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-3955-7896
Alicia DavisSchool of Social and Political Sciences/Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-1347-7708
Adrian MuwongeThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-8579-0384
Tiziana LemboThe Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-6405-1849

Funding

Biotechnology and Biological Sciences Research Council BB/P007767/1Biotechnology and Biological Sciences Research Council BBS/E/D/20002173Biotechnology and Biological Sciences Research Council BBS/E/D/20002174Medical Research Council MR/S004815/1Medical Research Council MR/V034952/1
6 · The paper itself

Abstract

Universal access to healthcare, including quality medicines, is a fundamental human right but is still out of reach for many in low- and middle-income countries (LMICs). An existing framework capturing variability of access to healthcare in low-resource settings includes the 5 dimensions: availability, accessibility, affordability, adequacy, and acceptability. This framework encompasses key components, including health infrastructure and means to access it as well as service organisation, costs, and factors that influence users' satisfaction. However, in reality, the effectiveness of accessed healthcare is measured by the likelihood of a positive outcome. We therefore propose an expansion of this framework to include an additional dimension, "aspects of quality," incorporating quality, which critically influences the ability of the accessed services to generate optimal health outcomes. Within this framework, we explore literature from East Africa likely relevant to a range of LMIC contexts, mainly focusing on the provision of widely used antimicrobials such as antimalarials and antibiotics. We argue that major inadequacies exist across all 6 dimensions of access and quality of drugs and their provision. While the global focus is on curbing excessive antimicrobial use to tackle the antimicrobial resistance (AMR) crisis, major constraints around access shape patients' health-seeking decisions leading to potentially problematic practices that might exacerbate the AMR problem. We advocate for a holistic approach to tackling these inadequacies, encompassing all dimensions of access and quality of healthcare in order to improve health outcomes while simultaneously counteracting the AMR crisis.

Indexed as

Drug Resistance, BacterialAfrica, EasternAnti-Bacterial AgentsBacteriaBacterial InfectionsHealth Services AccessibilityHumansQuality of Health CareAnti-Bacterial Agents

Identifiers

PMID34292932
PMCPMC8297743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.