Evidence map›Paper›PMID 34292926›Full record

GuidelineMMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports2021

Sexually Transmitted Infections Treatment Guidelines, 2021.

Kimberly A Workowski, Laura H Bachmann, Philip A Chan, Christine M Johnston, Christina A Muzny, Ina Park, Hilary Reno, Jonathan M Zenilman, Gail A Bolan

Erratum issued 4 registry-linked trialsOpen access · diamondAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 1,219 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,219citing papers in PubMed, 9 pooled it
228.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05132114 nacompletednot on this mapstarted 2022, after this paper: background citation

Large Loop Excision of the Transformation Zone (LLETZ) With Versus Without Intraoperative Application of Lugol's Iodine in Women With Cervical Dysplasia: a Prospective Randomized Trial

TypeinterventionalSponsorRuhr University of BochumRan2022 to 2025Enrolled230ConditionsCervical DysplasiaArmsLugol's iodine test
NCT05391243 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Performance of Large Loop Excision of the Transformation Zone (LLETZ) in Women with Cervical Dysplasia in the Follicular Phase Versus the Luteal Phase of the Menstrual Cycle: a Prospective Randomized Trial

TypeinterventionalSponsorRuhr University of BochumRan2025 to 2026Enrolled152ConditionsCervical DysplasiaArmsLLETZ
NCT05509413 nacompletednot on this mapstarted 2022, after this paper: background citation

DEFLAGYN® Vaginal Gel and Spontaneous Remission and Regression of Unclear Cervical Smears and HPV High-risk Infections

TypeinterventionalSponsorRuhr University of BochumRan2022 to 2025Enrolled242ConditionsCervix Dysplasia, HPV InfectionArmsDEFLAGYN vaginal gel
NCT05587283 phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Phase 1 Single-Centre, Double-Blind, Randomized, Placebo-Controlled, Multiple Ascending Dose Clinical Trial to Evaluate the Safety, Tolerability and Acceptability of Intravaginal Administration of LABTHERA-001 Capsules in Healthy Female Volunteers

TypeinterventionalSponsorAtoGen Co. LtdRan2022 to 2023Enrolled24ConditionsBacterial Vaginosis, Vaginal Disease, Bacterial Infections, VaginitisArmsExperimental: Low dose LABTHERA-001 capsule, Experimental: Medium dose LABTHERA-001 capsule, Experimental: High dose LABTHERA-001 capsule, Placebo Comparator: Low dose Placebo capsule, Placebo Comparator: Medium dose Placebo capsule
3 · Its place in the literature

Who cites it

1,219 citing papers in PubMed, 9 syntheses or guidelines pooled it, 2,366 citations in OpenAlex.

  1. Pooled it
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  12. Call for Increased Community Education Regarding Common HPV-Associated Cancers Within the Urban Safety-Net Hospital Population.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
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1,159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kimberly A Workowski
Laura H Bachmann
Philip A Chan
Christine M Johnston
Christina A Muzny
Ina Park
Hilary Reno
Jonathan M Zenilman
Gail A Bolan

Funding

The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019. The information in this report updates the 2015 guidelines. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4) management of Mycoplasma genitalium; 5) human papillomavirus vaccine recommendations and counseling messages; 6) expanded risk factors for syphilis testing among pregnant women; 7) one-time testing for hepatitis C infection; 8) evaluation of men who have sex with men after sexual assault; and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. Physicians and other health care providers can use these guidelines to assist in prevention and treatment of STIs.

Indexed as

Centers for Disease Control and Prevention, U.S.HumansSexually Transmitted DiseasesUnited States

Identifiers

PMID34292926
PMCPMC8344968
OpenAlexW3185444663

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.