Evidence map›Paper›PMID 34292742›Full record

ArticleThe Journal of organic chemistry2021

Self-Immolative System for Disclosure of Reactive Electrophilic Alkylating Agents: Understanding the Role of the Reporter Group.

Alexander G Gavriel, Flavien Leroux, Gurjeet S Khurana, Viliyana G Lewis, Ann M Chippindale, Mark R Sambrook, Wayne Hayes, Andrew T Russell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexander G GavrielDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
Flavien LerouxDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
Gurjeet S KhuranaDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
Viliyana G LewisDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
Ann M ChippindaleDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0002-5918-8701
Mark R SambrookCBR Division, Defence Science & Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, U.K.
Wayne HayesDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0003-0047-2991
Andrew T RussellDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0002-0576-2261
University of Reading · GBDefence Science and Technology Laboratory · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of stable, efficient chemoselective self-immolative systems, for use in applications such as sensors, requires the optimization of the reactivity and degradation characteristics of the self-immolative unit. In this paper, we describe the effect that the structure of the reporter group has upon the self-immolative efficacy of a prototype system designed for the disclosure of electrophilic alkylating agents. The amine of the reporter group (a nitroaniline unit) was a constituent part of a carbamate that functioned as the self-immolative unit. The number and position of substituents on the nitroaniline unit were found to play a key role in the rate of self-immolative degradation and release of the reporter group. The position of the nitro substituent (

Indexed as

Alkylating AgentsDisclosureCarbamatesAlkylating AgentsCarbamates

Identifiers

PMID34292742
PMCPMC8389931
OpenAlexW3183202122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.