Evidence map›Paper›PMID 34292611›Full record

ArticleJournal of cutaneous pathology2022

Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination.

Valerie Larson, Roy Seidenberg, Avrom Caplan, Nooshin K Brinster, Shane A Meehan, Randie H Kim

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cutaneous pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 7 pooled it
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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  13. Cutaneous reactions to vaccination.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Valerie LarsonThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Roy SeidenbergLaser & Skin Surgery Center of New York, New York, New York, USA.
Avrom CaplanThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Nooshin K BrinsterThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-9731-4115
Shane A MeehanThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Randie H KimThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0003-0365-5961
New York University · USLaser and Skin Surgery Center of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs more people become vaccinated against the SARS-CoV-2 virus, reports of delayed cutaneous hypersensitivity reactions are beginning to emerge.

methodsIn this IRB-approved retrospective case series, biopsy specimens of potential cutaneous adverse reactions from the Pfizer-BioNTech or Moderna mRNA vaccine were identified and reviewed. Clinical information was obtained through the requisition form, referring clinician, or medical chart review.

resultsTwelve cases were included. Histopathological features from two injection-site reactions showed a mixed-cell infiltrate with eosinophils and a spongiotic dermatitis with eosinophils. Three biopsy specimens came from generalized eruptions that showed interface changes consistent with an exanthematous drug reaction. Three biopsy specimens revealed a predominantly spongiotic pattern, consistent with eczematous dermatitis. Small-vessel vascular injury was seen in two specimens, which were diagnosed as urticarial vasculitis and leukocytoclastic vasculitis, respectively. There were two cases of new-onset bullous pemphigoid supported by histopathological examination and direct immunofluorescence studies. Eosinophils were seen in 10 cases.

conclusionsDermatopathologists should be aware of potential cutaneous adverse reactions to mRNA-based COVID-19 vaccines. Histopathological patterns include mixed-cell infiltrates, epidermal spongiosis, and interface changes. Eosinophils are a common finding but are not always present. Direct immunofluorescence studies may be helpful for immune-mediated cutaneous presentations such as vasculitis or bullous pemphigoid.

Indexed as

2019-nCoV Vaccine mRNA-1273AdultAgedAged, 80 and overBiopsyBNT162 VaccineCOVID-19COVID-19 VaccinesDermatitisDrug-Related Side Effects and Adverse ReactionsEosinophilsFemaleFluorescent Antibody Technique, DirectHumansHypersensitivity, DelayedMale2019-nCoV Vaccine mRNA-1273BNT162 VaccineCOVID-19 VaccinesCOVID-19cutaneous adverse reactionvaccine

Identifiers

PMID34292611
PMCPMC8444807
OpenAlexW3185683543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.