Evidence map›Paper›PMID 34292609›Full record

Observational studyHepatology (Baltimore, Md.)2021

HBV Genotype: A Significant Risk Factor in Determining Which Patients With Chronic HBV Infection Should Undergo Surveillance for HCC: The Hepatitis B Alaska Study.

Brian J McMahon, Leisha D Nolen, Mary Snowball, Chriss Homan, Susan Negus, Elena Roik, Philip R Spradling, Dana Bruden

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Hepatology (Baltimore, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  9. Article
  10. Article
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  12. Guidelines for the Prevention and Treatment of Chronic Hepatitis B (version 2022).Journal of clinical and translational hepatology · 2023
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. [Guidelines for the prevention and treatment of chronic hepatitis B (version 2022)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Brian J McMahonLiver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK, USA.
Leisha D NolenDivision of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Arctic Investigations Program, Anchorage, AK, USA.
Mary SnowballLiver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK, USA.
Chriss HomanDivision of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Arctic Investigations Program, Anchorage, AK, USA.
Susan NegusLiver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK, USA.
Elena RoikDivision of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Arctic Investigations Program, Anchorage, AK, USA.
Philip R SpradlingDivision of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Arctic Investigations Program, Anchorage, AK, USA.
Dana BrudenLiver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK, USA.
Centers for Disease Control and Prevention · USNational Center for Emerging and Zoonotic Infectious Diseases · USNational Center for HIV/AIDS Viral Hepatitis STD and TB Prevention · US

Funding

NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLEU01PS001097 · PS · ALASKA NATIVE TRIBAL HEALTH CONSORTIUM · PI MCMAHON, BRIAN JAMES · 2008 to 2012
$1.3M
NCHHSTP CDC HHS U01 PS001097
6 · The paper itself

Abstract

BACKGROUND AND

aimsInformation is limited regarding HBV genotype and the outcome of chronic HBV (CHB) infection. We examined the effect of HBV genotype on HCC occurrence in Alaska Native (AN) persons with CHB, where five HBV genotypes are found: A2, B6, C2, D, and F1. APPROACH AND

resultsWe calculated HCC incidence per 1,000 person-years of follow-up to determine which groups by age, sex, and genotype met current American Association for the Study of Liver Diseases (AASLD) HCC surveillance criteria. We used Poisson regression to compare HCC risk by genotype, age, sex, and Alaska region. Incidence of HCC was calculated using the sex-specific AASLD cutoff recommended for the Asian population of 50 years for women and 40 years for men. HCC screening was conducted semiannually using alpha-fetoprotein levels and abdominal ultrasound. Among 1,185 AN persons, median follow-up was 35.1 years; 667 (63%) were male. The HBV genotype distribution was 49% D, 18% F, 13% A, 6% C, 3% B, 0.1% H, and 12% undetermined. Sixty-three cases of HCC occurred. HCC incidence for genotype F was 5.73 per 1,000 person-years of follow-up, followed by 4.77 for C, 1.28 for A, 0.47 for D, and 0.00 for B. The HCC risk was higher for genotypes F (relative rate [RR], 12.7; 95% CI, 6.1-26.4), C (RR, 10.6; 95% CI, 4.3-26.0), and A (RR, 2.9; 95% CI, 1.0-8.0) compared to genotypes B and D. Among men < 40 years of age and women < 50 years of age, genotype F had the highest incidence (4.79/1,000 person-years).

conclusionsHBV genotype was strongly associated with HCC. HBV genotype should be considered in risk factor stratification.

Indexed as

AdolescentAdultAge FactorsAlaskaCarcinoma, HepatocellularChildFemaleFollow-Up StudiesGenotyping TechniquesHepatitis B, ChronicHepatitis B virusHumansIncidenceLiver NeoplasmsMaleMiddle Aged

Identifiers

PMID34292609
PMCPMC10929546
OpenAlexW3185970357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.