ArticleDevelopmental psychobiology2021
Maternal trait anxiety symptoms, frontolimbic resting-state functional connectivity, and cognitive development in infancy.
Article in Developmental psychobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Perinatal hardship and infant neurodevelopment: insights from a global pandemic.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Engage & connect psychotherapy improves social reward responsivity and reduces postpartum depression.Psychotherapy research : journal of the Society for Psychotherapy Research · 2025Article
- COVID-19 Pandemic-Related Prenatal Distress and Infant Functional Brain Development.JAACAP open · 2025Article
- Preventive Psychological Interventions for the Management of Perinatal Anxiety: A Systematic Review.Brain sciences · 2025Review
- Functional connectivity characteristics of epilepsy with anxiety: A resting-state functional near-infrared spectroscopy study.Medicine · 2025Observational
- Neurobiological and Behavioral Underpinnings of Perinatal Mood and Anxiety Disorders (PMADs): A Selective Narrative Review.Journal of clinical medicine · 2024Review
- Neural Network Functional Interactions Mediate or Suppress White Matter-Emotional Behavior Relationships in Infants.Biological psychiatry · 2023Article
- The maternal brain is more flexible and responsive at rest: effective connectivity of the parental caregiving network in postpartum mothers.Scientific reports · 2023Article
- Postnatal maternal distress, infant subcortical brain macrostructure and emotional regulation.Psychiatry research. Neuroimaging · 2023Article
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5 authors.
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Abstract
Exposure to maternal anxiety symptoms during infancy has been associated with difficulties in development and greater risk for developing anxiety later in life. Although previous studies have examined associations between prenatal maternal distress, infant brain development, and developmental outcomes, it is still largely unclear if there are associations between postnatal anxiety, infant brain development, and cognitive development in infancy. In this study, we used resting-state functional magnetic resonance imaging to examine the association between maternal anxiety symptoms and resting-state functional connectivity in the first year of life. We also examine the association between frontolimbic functional connectivity and infant cognitive development. The sample consisted of 21 infants (mean age = 24.15 months, SD = 4.17) that were scanned during their natural sleep using. We test the associations between maternal trait anxiety symptoms and amygdala-anterior cingulate cortex (ACC) functional connectivity, a neural circuit implicated in early life stress exposure. We also test the associations between amygdala-ACC connectivity and cognitive development. We found a significant negative association between maternal trait anxiety symptoms and left amygdala-right ACC functional connectivity (p < .05, false discovery rate corrected). We found a significant negative association between left amygdala-right ACC functional connectivity and infant cognitive development (p < .05). These findings have potential implications for understanding the role of postpartum maternal anxiety symptoms in functional brain and cognitive development in infancy.
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