Evidence map›Paper›PMID 34292477›Full record

ReviewGeroScience2022

Slowing down as we age: aging of the cardiac pacemaker's neural control.

Sabrina Choi, Matthias Baudot, Oscar Vivas, Claudia M Moreno

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in GeroScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025
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  12. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sabrina ChoiDepartment of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA.
Matthias BaudotDepartment of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA.
Oscar VivasDepartment of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA.
Claudia M MorenoDepartment of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA. morenocm@uw.edu.ORCID 0000-0001-8397-3649

Funding

Mechanisms behind the clustering of BK and calcium channelsR35GM142690 · NIGMS · UNIVERSITY OF WASHINGTON · PI VIVAS, OSCAR · 2021 to 2025
$1.9M
Changes in L-type calcium channels during aging in the heart's pacemakerR00AG056595 · NIA · UNIVERSITY OF WASHINGTON · PI MORENO, CLAUDIA MARCELA · 2019 to 2021
$747k
NIA NIH HHS R00 AG056595NIGMS NIH HHS R35 GM142690
6 · The paper itself

Abstract

The cardiac pacemaker ignites and coordinates the contraction of the whole heart, uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the autonomous nervous system to maintain body homeostasis. Sympathetic and parasympathetic terminals act over the pacemaker cells as the accelerator and the brake pedals, increasing or reducing the firing rate of pacemaker cells to match physiological demands. Despite the remarkable reliability of this tissue, the pacemaker is not exempt from the detrimental effects of aging. Mammals experience a natural and continuous decrease in the pacemaker rate throughout the entire lifespan. Why the pacemaker rhythm slows with age is poorly understood. Neural control of the pacemaker is remodeled from birth to adulthood, with strong evidence of age-related dysfunction that leads to a downshift of the pacemaker. Such evidence includes remodeling of pacemaker tissue architecture, alterations in the innervation, changes in the sympathetic acceleration and the parasympathetic deceleration, and alterations in the responsiveness of pacemaker cells to adrenergic and cholinergic modulation. In this review, we revisit the main evidence on the neural control of the pacemaker at the tissue and cellular level and the effects of aging on shaping this neural control.

Indexed as

AgingSinoatrial NodeAnimalsHeart RateReproducibility of ResultsAutonomic controlCardiac agingCardiac pacemakerHeart rate

Identifiers

PMID34292477
PMCPMC8811107

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.